摘要
目的探讨无症状体检人群幽门螺杆菌(Helicobacter pylori,H.pylori)感染与代谢综合征(metabolic syndrome,MS)及胃十二指肠黏膜改变的关系。方法采用回顾性研究方法,选取2017年10月至2018年10月在徐州医科大学附属医院体检中心同时进行包括14 C尿素呼气试验、生化指标、空腹血糖(FBG)及收缩压(SBP)/舒张压(DBP)和体质量指数(BMI)等一般资料及病史完整者7527例,其中同时完善胃镜检查者1241例。根据14 C尿素呼气试验结果分为H.pylori阳性组和H.pylori阴性组。比较两组一般资料、代谢指标、MS患病率及胃炎、胃炎伴糜烂、胃溃疡、十二指肠溃疡、胃息肉患病率。将MS患者分为H.pylori阳性组与H.pylori阴性组,比较两组一般资料。比较不同年龄段H.pylori感染率与MS患病率的关系。结果H.pylori感染的发生率为42.75%,MS的患病率为20.99%。H.pylori阳性组与H.pylori阴性组比较,MS患病率、胃溃疡患病率、十二指肠溃疡患病率、BMI、SBP、总胆固醇(CHOL)水平、甘油三脂(TG)水平明显升高(P<0.05)。MS患者中H.pylori阳性组的BMI、DBP、CHOL水平显著升高。随着年龄增长,MS的患病率逐渐升高,75岁以上人群MS患病率最高(37.56%),H.pylori感染阳性率最高为46~60岁人群(43.90%)。16~30岁人群:H.pylori阳性组DBP、FBG水平较H.pylori阴性组高,HDL-C水平较H.pylori阴性组低;31~45岁人群:H.pylori阳性组BMI、DBP、TG水平较H.pylori阴性组高;46~60岁人群:H.pylori阳性组BMI、DBP、SBP、CHOL水平较H.pylori阴性组高;61~75岁人群:H.pylori阳性组DBP水平较H.pylori阴性组高;对于75岁以上人群H.pylori阳性组与阴性组代谢指标比较,差异无统计学意义(P>0.05)。MS患者中H.pylori阳性组的BMI、DBP、CHOL水平显著升高。H.pylori阳性组中有胃炎伴糜烂或有消化性溃疡者BMI、SBP、DBP、TG、CHOL水平高于轻度胃炎者(P<0.05)。结论H.pylori感染不仅引起胃黏膜损伤,同时增加MS的患病风险,并促�
Objective To explore the association of Helicobacter pylori(H.pylori)infection with gastroduodenal mucosa changes with metabolic syndrome(MS)in a Chinese population.Methods There was a cross-sectional study that included 7527 participants who underwent a 14 C-urea breath test at the Physical Examination Center in the Affiliated Hospital of Xuzhou Medical University from Oct.2017 to Oct.2018,data on the results of 14 C-urea breath test,biochemical variables,fasting blood glucose(FBG),blood pressure(SBP and DBP),body mass index(BMI)and medical history were detected.During the period,1241 cases of gastroscopy were completed simultaneously.According to the results of carbon 14 C-urea breath test,the patients were divided into H.pylori positive group and H.pylori negative group.Multivariate analysis was performed to assess the relationship between H.pylori infection and the prevalence of MS.Results The incidence of H.pylori infection was 42.75%and the prevalence of MS was 20.99%.Compared with H.pylori negative group,the prevalence of MS,gastric ulcer,duodenal ulcer,body mass index(BMI),systolic blood pressure(SBP),total cholesterol(CHOL),triglyceride(TG)were significantly increased in H.pylori positive group(P<0.05).Levels of BMI,DBP,and CHOL were significantly increased in H.pylori positive group of patients with MS.The prevalence of MS increased with age,the highest prevalence of MS in people over 75 years old was 37.56%and the highest positive rate of H.pylori infection in people aged 46-60 years old was 43.90%.In 16-30 years old,the levels of DBP and FBG in the H.pylori positive group were higher than those in the H.pylori negative group,and the level of HDL-C was lower than that in the H.pylori negative group.In 31-45 years old,the levels of BMI,DBP and TG in H.pylori positive group were higher than those in H.pylori negative group.In 46-60 years old,the levels of BMI,DBP,SBP and CHOL in H.pylori positive group were higher than those in H.pylori negative group.In 61-75 years old,the level of DBP in H.pylori posit
作者
张鹏
陈剑群
ZHANG Peng;CHEN Jianqun(Graduate School of Xuzhou Medical University,Xuzhou 221000;Department of Gastroenterology,Affiliated Hospital of Xuzhou Medical University,China)
出处
《胃肠病学和肝病学杂志》
CAS
2019年第12期1368-1374,共7页
Chinese Journal of Gastroenterology and Hepatology
