摘要
目的探讨基于主题模型的急性心肌梗死的不同兼症及合并病中医治疗方案优化方法.方法选择“临床科研一体化平台”数据库中急性心肌梗死患者624例.采集患者的临床信息包括基本信息、临床主要症状、中医证候、兼症、合并病及治疗用药等,数据在预处理后进行分析挖掘.以中医兼症、证候要素及中药作为研究主题,应用主题模型法分析主题1、2、3中特定证候要素、兼症的中药用药规律,以合并病、急性心肌梗死证候要素及中药作为研究主题,分析主题4、5、6中特定证候要素、合并病的中药用药规律.结果中医兼症、中药及证候要素主题1中,咳嗽、头晕、头痛、自汗是急性心肌梗死血瘀痰浊患者常见中医兼症的症状表现,该类证候要素、兼症群所对应使用的中药及分布概率为川芎(0.140)、茯苓(0.061)、枳壳(0.061)、瓜蒌(0.053);主题2中,恶心呕吐、气喘、口干欲饮、肢体麻木是急性心肌梗死气虚血瘀痰浊证患者常见中医兼症的症状表现,该类证候要素、兼症群所对应使用的中药及分布概率为丹参(0.224)、五味子(0.122)、黄芪(0.102)、陈皮(0.071);主题3中,自汗、恶心呕吐、咯痰、肢凉是急性心肌梗死气虚血瘀兼见痰浊证患者常见中医兼症的症状表现,该类证候要素、兼症群所对应使用的中药及分布概率为桃仁(0.122)、延胡索(0.089)、佩兰(0.081)、麦冬(0.065).急性心肌梗死证候要素、合并病、中药关系主题4中,急性心肌梗死气虚血瘀痰浊证患者常见高血压、糖尿病、肺部感染、中风等合并病,该类证候要素、合并病群所对应使用的中药及分布概率为黄芪(0.147)、陈皮(0.130)、甘草(0.122)、川芎(0.107);主题5中,急性心肌梗死气虚血瘀痰浊证患者常见高血压、高脂血症、糖尿病、中风等合并病,该类证候要素、合并病群所对应使用的中药及分布概率为当归(0.144)、赤芍(0.115)�
Objective To explore the optimization methods of traditional Chinese medicine(TCM)treatment for acute myocardial infarction(AMI)with different accompanied symptoms and comorbidities based on the topic model.Methods Clinical data of 624 patients with AMI were retrieved from the"Integrated Platform for Clinical Scientific Research"database.Basic information,main symptoms,TCM syndromes,accompanied symptoms,comorbidities and medication were collected.Topic model analysis was performed using accompanied symptoms,syndrome elements and medication information in topics 1,2,3 and using comorbidities,syndrome elements and medication information in topics 4,5,6.Results Topic 1 suggested that cough,dizziness,headache and spontaneous sweating were common symptoms of AMI with blood stasis and phlegm turbidity;the recommended Chinese herbal medicines and the distribution probabilities were Ligusticum wallichii(0.140),Poria cocos(0.061),Fructus aurantii(0.061)and Fructus trichosanthes(0.053).Topic 2 suggested that nausea and vomiting,asthma,dry mouth,limb numbness were common symptoms of AMI with qi deficiency,blood stasis and phlegm turbidity;the recommended Chinese herbal medicines and the distribution probabilities were Salvia miltiorrhiza(0.224),Schisandra chinensis(0.122),Astragalus membranaceus(0.102)and Dried tangerine peel(0.071).Topic 3 suggested that spontaneous sweating,nausea and vomiting,phlegm and limb coolness were common symptoms of TCM with Qi deficiency,blood stasis and phlegm turbidity;the recommended Chinese herbal medicines and the distribution probabilities were Peach kernel(0.122),Corydalis tuber(0.089),Eupatorium(0.081)and Radix ophiopogonis(0.065).Topic 4 suggested that hypertension,diabetes,pulmonary infection and stroke were common comorbdities of AMI with qi deficiency,blood stasis and phlegm turbidity;the recommended Chinese herbal medicines and the distribution probabilities were Astragalus membranaceus(0.147),Dried tangerine peel(0.130),Licorice(0.122)and Ligusticum wallichii(0.107).Topic 5 suggest
作者
冯妍
王以新
马涵英
康晨瑜
徐浩
周雪忠
Feng Yan;Wang Yixin;Ma Hanying;Kang Chenyu;Xu Hao;Zhou Xuezhong(Department of General Medical Practice,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Department of Cardiovascular Medicine,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;School of Computer and Information Technology,Beijing Jiaotong University,Beijing 100044,China)
出处
《中国医药》
2019年第12期1769-1773,共5页
China Medicine
基金
国家自然科学基金(81703932)
北京市教育委员会首都全科医学研究专项课题(17QK23)~~
关键词
急性心肌梗死
中医治疗
主题模型
Acute myocardial infarction
Traditional Chinese medicine
Topic model
