摘要
目的:探究炎性反应标志物对新生儿(出生后0~28天)先天性心脏病(CHD)的临床预测价值,为新生儿CHD的预防、诊治提供理论指导依据。方法:通过病历调查进行收集相关资料,包括孕母孕早期血常规中性粒细胞计数、淋巴细胞计数、血小板计数,并计算中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)。分析PLR、NLR的ROC曲线,计算cut off值、敏感度、特异性。结果:孕母孕期NLR及PLR值增高,会导致后代患CHD风险升高。当孕母妊娠期NLR>4.309和(或)PLR值>101.556时,子代CHD发生的风险明显增加。结论:母亲妊娠期NLR>4.309和(或)PLR值>101.556时,子代CHD发生的风险明显增加,且NLR与CHD相关性更强。
Objective This paper means to figure out what value the inflammatory makers could have in clinical forcast of Congenital heart disease of neonatus.Then the result of this paper could guide doctors to prevent and give effective treatment to CHD of neonatus and ease the pressure of families and society.Method The related data would be collected by investigating medical record,including Neutrophil,lymphocyte and Platelet in early gestational period.Then figure out Neutrophil-lymphocyte ratio(NLR)and Platelet-lymphocyte ratio(PLR).Then the paper would analyze ROC curves of PLR and NLR.And calculate cut off value,sensitivity and specificity.Results There was a positive correlation between the risk of CHD occurrence among new born babiesand their mothers'PLR and NLR value during pregnancy.The chart showed that the risk of falling CHD would be markedly increased when mothers'NLR value was over 4.039 or PLR value went beyond 101.556.The NLR value was more accurate because of a larger area under curve.Conclusion The risk of falling CHD will be markedly increased when mothers'NLR value is over 4.039 or PLR value goes beyond 101.556.The NLR value is more accurate because of a larger area under curve.
作者
哈桑
尹永日
苏立明
HA Sang;YIN Yong-ri;SU Li-ming(Yanbian University Hospital,Yanji 133000,China)
出处
《吉林医学》
CAS
2019年第12期2712-2714,共3页
Jilin Medical Journal
