摘要
目的:探讨慢性阻塞性肺疾病(COPD)并发肺动脉高压(PAH)患者血清微小RNA-130a(miR-130a)、中性粒细胞与淋巴细胞比值(NLR)、胸部血管CT参数变化及其与病情程度的关系。方法:选取COPD并发PAH患者103例为COPD+PAH组,选取COPD但不并发PAH患者107例为COPD组,比较两组血清miR-130a、NLR、肺血管CT参数、肺功能及肺动脉收缩压。根据PAH程度将103例COPD+PAH组患者进一步分为轻度组、中度组和重度组,比较三组血清miR-130a、NLR和胸部血管CT参数。分析COPD并发PAH患者肺动脉收缩压与miR-130a、NLR、胸部血管CT参数的相关性。结果:COPD+PAH组血清miR-130a、NLR水平以及肺动脉直径(MPAD)、降主动脉直径(DAD)、升主动脉直径(AAD)高于COPD组(均P<0.05)。COPD+PAH组肺动脉收缩压高于COPD组,肺一氧化碳弥散能力(DLCO)预计值低于COPD组(均P<0.05)。重度组miR-130a、NLR水平以及MPAD、DAD、AAD高于中度组和轻度组,且中度组上述指标高于轻度组(均P<0.05)。COPD并发PAH患者肺动脉收缩压与miR-130a、NLR、MPAD、DAD、AAD呈正相关(均P<0.05)。结论:COPD并发PAH患者miR-130a、NLR水平升高,肺部MPAD、DAD、AAD增大,并且与患者PAH程度关系密切。
Objective:To explore the changes of serum miR-130a,neutrophil to lymphocyte ratio(NLR)and CT parameters of thoracic vessels in patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary arterial hypertension(PAH)and their relationship with disease severity.Methods:A total of 103 patients with COPD complicated with PAH were selected as the COPD+PAH group,and 107 patients with COPD but without PAH were selected as the COPD group.The serum miR-130a,NLR,pulmonary vascular CT parameters,pulmonary function and pulmonary artery systolic pressure were compared between the two groups.According to the degree of PAH,103 patients in the COPD+PAH group were further divided into mild group,moderate and severe groups,and the serum miR-130a,NLR and pulmonary vascular CT parameters were compared among the three groups.The correlation between pulmonary artery systolic pressure and miR-130a,NLR,CT parameters of thoracic vessels in COPD patients with PAH was analyzed.Results:Compared with the COPD group,the COPD+PAH group had significantly higher levels of miR-130a,NLR,MPAD,DAD and AAD(all P<0.05).Pulmonary artery systolic pressure in COPD+PAH group was higher than that in COPD group,and lung DLCO estimated value was lower than that in COPD group(all P<0.05).The levels of miR-130a,NLR,MPAD,DAD and AAD in the severe group were higher than those in the moderate and mild groups,and the above indexes in the moderate group were higher than those in the mild group(all P<0.05).Pulmonary artery systolic pressure was positively correlated with miR-130a,NLR,MPAD,DAD and AAD in patients with COPD complicated with PAH(all P<0.05).Conclusion:The levels of miR-130a and NLR in COPD patients with PAH are increased,and MPAD,DAD and AAD are increased,which are closely related to the degree of PAH in patients.
作者
张芝瑞
张艳
李俊杰
黄杨
王玉同
赵威
张斌
ZHANG Zhirui;ZHANG Yan;LI Junjie;HUANG Yang;WANG Yutong;ZHAO Wei;ZHANG Bin(The First Affiliated Hospital of Air Force Medical University,Xi’an 710032,China)
出处
《陕西医学杂志》
CAS
2024年第12期1640-1644,共5页
Shaanxi Medical Journal
基金
陕西省重点研发计划项目(S2020-YF-YBSF-1186)。
