摘要
目的分析妊娠高血压疾病(PIH)患者血清胎盘生长因子(PLGF)、可溶性血管内皮生长因子受体1(sFlt1)及脂联素(APN)的表达水平及其相关性。方法选取2017年5月至2019年1月确诊的111例PIH患者(观察组)及同期产检的38例(对照组)健康孕妇作为研究对象。观察组根据疾病情况分为妊娠高血压组(GH组,31例)、先兆性子痫组(PE组,40例)和子痫组(EG组,40例)。比较4组研究对象血清PLGF、sFlt1及APN水平,并分析观察组各指标间的相关性。结果 GH组血清PLGF、APN水平低于对照组,血清sFlt1水平高于对照组(P<0.05);PE组血清PLGF、APN水平低于GH组(P<0.05),血清sFlt1水平高于GH组;EG组血清PLGF、APN水平低于PE组,血清sFlt1水平高于PE组(P<0.05)。观察组患者血清PLGF与sFlt1水平呈负相关,PIGF与APN水平呈正相关,sFlt1与APN水平呈负相关(P<0.05)。结论血清PLGF、sFlt1、APN水平与PIH的发生发展密切相关,且各指标间具有明显相关性,因此可作为PIH诊断及治疗效果评估的生物学指标。
Objective To analyze the expression levels and correlation of serum placental growth factor(PLGF), soluble vascular endothelial growth factor receptor 1(sFlt1) and adiponectin(APN) in patients with pregnant-induced hypertension(PIH). Methods A total of 111 PIH patients(observation group) diagnosed from May 2017 to January 2019 and 38 healthy pregnant women(control group) in the same period of labor examination were selected as the study objects. The observation group was divided into pregnancy hypertension group(GH group, 31 cases), preeclampsia group(PE group, 40 cases) and eclampsia group(EG group, 40 cases) according to the disease. The levels of serum PLGF, sflt1 and APN were compared among the four groups, and the correlation among the indexes of the observation group was analyzed. Results The levels of serum PLGF and APN in the GH group were lower than those in the control group, and the level of serum sFlt 1 was higher than that in the control group(P <0.05);the levels of serum PLGF and APN in the PE group were lower than those in the GH group(P<0.05), and the level of serum sFlt1 was higher than that in the GH group;the levels of serum PLGF and APN in the EG group were lower than those in the PE group, and the level of serum sFlt1 was higher than that in the PE group(P<0.05). In the observation group, the level of serum PLGF was negative correlation with the level of sFlt1, the level of PLGF was positively correlated with the level of APN, and the level of SFlt1 was negatively correlated with the level of APN(P <0.05). Conclusion The levels of serum PLGF, sFlt1 and APN are closely related to the development of PIH, and there is a significant correlation between each index. Therefore, the indexes can be used as a biological index for the diagnosis and treatment effect evaluation of PIH.
作者
齐红燕
杨爱君
李海燕
QI Hong-yan;YANG Ai-jun;LI Hai-yan(Obstetrics and Gynecology Department,Xi'an Fourth Hospital,Xi'an 710004,China;Pharmaceutical Department,Xi'an Fourth Hospital,Xi'an 710004,China)
出处
《临床医学研究与实践》
2019年第34期40-41,共2页
Clinical Research and Practice
基金
学科发展科技支持项目（No.FZ-9）
关键词
妊娠高血压疾病
胎盘生长因子
可溶性血管内皮生长因子受体1
脂联素
pregnant -induced hypertension
placental growth factor
soluble vascular endothelial growth factor receptor 1
adiponectin
