摘要
目的评价活性维生素D治疗2型糖尿病肾病有效性及安全性。方法计算机检索Cochrane library、Pubmed、Embase数据库。应用RevMan5.2软件进行统计分析。结果治疗组显著减少24 h尿蛋白[OR=0.28,95%CI(0.24,0.33),P<0.00001],高血钙不良事件发生率较对照组有显著性差异[OR=4.86,95%CI(1.09,21.56),P=0.04]。结论活性维生素D治疗2型糖尿病肾病,显著降低患者24 h尿蛋白,但增加高血钙不良事件发生的风险。
Objective To evaluate the efficacy of active vitamin D in the treatment of type 2 diabetic nephropathy.Evaluating the safety of active vitamin D in the treatment of type 2 diabetic nephropathy.Methods We retrieved the Cochrane library,Pubmed,Embase databases and other relevant literatures.Meta-analysis was performed using RevMan5.2 software.Results Meta-analysis outcomes showed that vitamin D treatment group significantly reduced 24-hour urine protein[OR=0.28,95%CI(0.24,0.33),P<0.00001].There was statistical difference in high calcium blood[OR=4.86,95%CI(1.09,21.56),P=0.04].Conclusion In this meta-analysis,the use of active vitamin D in the treatment of type 2 diabetic nephropathy can significantly reduce 24-hour urinary protein,but increase the risk of hypercalcemia.
作者
张欣
程刚
ZHANG Xin;CHENG Gang(College of Life Sciences and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China;Liaoning Health Industry Group Fukuang General Hospital,Fushun 113008,China;College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《药学研究》
CAS
2019年第11期671-675,共5页
Journal of Pharmaceutical Research
