摘要
目的探究维生素D辅助治疗对老年女性糖尿病肾病(DKD)患者25⁃羟基维生素D[25⁃(OH)D]、甲状旁腺激素(PTH)、骨钙蛋白(BGP)、β⁃胶原特殊序列(β⁃CTX)及微炎症状态的影响。方法将2019年1月至2022年2月在北京世纪坛医院就诊的102例DKD患者按随机数字表法分为对照组和观察组,各51例,对照组给予常规治疗,观察组口服维生素D辅助治疗。检测患者空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、尿白蛋白(Alb)、血尿素氮(BUN)、血肌酐(Scr)、尿白蛋白排泄率(UAER)、C反应蛋白(CRP)、肿瘤坏死因子⁃α(TNF⁃α)、白介素⁃6(IL⁃6)。结果治疗1个月后,两组患者HbA1c、FPG、2 hPG、空腹胰岛素FINS较治疗前均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组患者UAER、BUN、Scr较治疗前均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组患者25⁃(OH)D、BGP较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05),两组患者PTH、β⁃CTX较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组患者CRP、TNF⁃α、IL⁃6较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论维生素D辅助治疗能有效改善老年女性DKD患者血糖水平及肾功能障碍,调节骨代谢指标,改善微炎症状态。
Objective To investigate the effect of vitamin D(VD)adjuvant therapy on 25⁃hydroxyvitamin D[25⁃(OH)D],parathyroid hormone(PTH),bone gla protein(BGP),β⁃CTX and micro⁃inflammatory state in elderly female patients with diabetic kidney disease(DKD).Methods A total of 102 patients with DKD admitted to Beijing Shijitan Hospital from January 2019 to February 2022 were divided into the control group and the observation group by random number table method with 51 cases in each group.The control group received conventional treatment,and the observation group received oral vitamin D adjuvant therapy.fasting plasma glucose(FPG),2 h postprandial plasma glucose(2 hPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS),urine albumin(Alb),blood urea nitrogen(BUN),serum creatinine(Scr),urinary albumin excretion rate(UAER),C⁃reactive protein(CRP),tumor necrosis factor⁃α(TNF⁃α),and interleukin⁃6(IL⁃6)were detected.Results After 1 month of treatment,HbA1c,FPG,2 hPG,FINS,UAER,BUN,and Scr in the two groups decreased(P<0.05),and these indicator in the observation group were lower than those in the control group(P<0.05).25⁃(OH)D and BGP in the two groups increased(P<0.05),and the two in the observation group were higher than those in the control group(P<0.05).PTH andβ⁃CTX in the two groups decreased(P<0.05),and the two in the observation group were lower than those in the control group(P<0.05).CRP,TNF⁃α,and IL⁃6 in the two groups decreased(P<0.05),and these indicators in the observation group were lower than those in the control group(P<0.05).Conclusion VD adjuvant therapy can effectively improve blood glucose level and renal dysfunction,regulate bone metabolism markers,and improve micro⁃inflammatory state in elderly female patients with DKD.
作者
侯言涛
温小军
白艳艳
王旭
HOU Yantao;WEN Xiaojun;BAI Yanyan;WANG Xu(General Department of Cadres,Beijing Shijitan Hospital,Capital Medical University,Beijing,China,100038)
出处
《分子诊断与治疗杂志》
2022年第12期2188-2191,2197,共5页
Journal of Molecular Diagnostics and Therapy
基金
北京市科技计划课题(Z191100001718132)。
