摘要
IgA肾病(Immunoglobulin A nephropathy,IgAN)是全世界范围内最常见的原发性肾小球肾炎,也是我国导致慢性肾脏疾病(Chronic kidney disease,CKD)最常见的原因之一。IgAN的发病机制目前仍不清楚,低糖基化IgA1(galactose deficient IgA1,gd-IgA1)以及它形成的免疫复合物在肾小球系膜区沉积是导致IgAN的主要因素。Th细胞因子(T helper cytokines)是由Th细胞分泌的具有广泛生物学活性的小分子多肽。近来,许多研究均表明Th细胞因子广泛参与IgAN。本文就此作一综述。
Immunoglobulin A nephropathy(IgAN)is the most common type of primary glomerulonephritis worldwild and the most common cause of chronic kidney disease(CKD)in China.its pathogenesis is still unclear.The key cause of this disease is the deposition of galactose deficient IgA1 and immune complexes in the glomerular mesangial area.Th cytokines are small molecular polypeptides secreted by Th cells with a wide range of biological activities.Recently,many studies have shown that Th cytokines are widely involved in IgAN.This article gives a review of this.
作者
郭艳
赵成波
谢富华
王润秀
GUO Yan;ZHAO Cheng-bo;XIE Fu-hua;WANG Run-xiu(Gannan Medical University,Ganzhou,Jangxi 341000;Gannan Medical University,School of Basic Medicine,Ganzhou,Jangxi 341000;Gannan Medical University,The First Affiliated Hospital,Ganzhou,Jangxi 341000)
出处
《赣南医学院学报》
2019年第10期1063-1066,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
