摘要
IgA肾病是全球最常见的免疫相关性肾小球疾病,以肾小球系膜区低糖基化IgA1沉积为主要病理特征。免疫调节紊乱在IgA肾病发病机制中起着重要的作用。T和B淋巴细胞的活化异常,可导致机体产生大量的低糖基化IgA1。
IgA nephropathy(IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide.The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli.Dysregulation of the immune system plays an important role in the pathogenesis of IgAN.Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2014年第1期96-101,共6页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81170663
81373227)
湖南省自然科学基金(12JJ6094)~~
关键词
IGA肾病
免疫学
分子机制
治疗靶点
IgA nephropathy
immunology
molecular mechanism
drugable target
