摘要
目的探究小叶榕对大鼠慢性支气管炎的防治作用及其机制。方法以小叶榕干浸膏给药,采用二氧化硫熏致慢性支气管炎的方法,构建大鼠慢性支气管炎模型;进行大鼠行为学考察,肺组织切片病变程度观察,肿瘤坏死因子(TNF-α)、肺组织匀浆中炎性细胞因子白细胞介素-4(IL-4)、白细胞介素-10(IL-10)水平检测。结果各给药组有不同程度支气管周围炎症与间质炎及气肿情况减轻,能够降低慢性支气管炎大鼠肺组织匀浆内TNF-α水平,并升高IL-4、IL-10水平,与模型组比较差异具有统计学意义(P <0.05)。结论初步证明小叶榕对慢性支气管炎的治疗有一定疗效,其对慢性支气管炎的治疗作用可能与其对炎性细胞因子的调控有关。
Objective To determine the preventive and therapeutic effect of Ficus concinna Miq. extract on chronic bronchitis and its mechanism. Methods The rat model of chronic bronchitis was established with smoking of sulfur dioxide. In addition, the behaviors of the rats and pathological changes of the lung tissues were observed while the levels of inflammatory cytokines(TNF-α, IL-4, and IL-10) in the lung homogenate were detected. Results Compared with the normal group, all the treatment groups showed different therapeutic effect of various degrees, with almost no peribronchial inflammation, mild interstitial inflammation and emphysema change. Meanwhile, the level of TNF-α were lowered, while the level of IL-10 and IL-4 increased in the lung tissue of rats with chronic bronchitis in the homogenate, with statistical significance(P < 0.05). Conclusion The extract of Ficus concinna Miq. has preventive and therapeutic effect on chronic bronchitis, which may be related to the level of inflammatory cytokines in the lung, and also to the cytokine regulation.
作者
秦飞
卢棚德
高展旺
张昕
陈焕鑫
卓清缘
莫尊汇
赖小平
王羚郦
QIN Fei;LU Peng-de;GAO Zhan-wang;ZHANG Xin;CHEN Huan-xin;ZHUO Qing-yuan;MO Zun-hui;LAI Xiao-ping;WANG Ling-li(Guangzhou BaiYunShan Pharmaceutical Holdings Co.,Ltd.,BaiYunShan Pharmaceutical General Factory,Guangzhou 510515;School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006;Mathematical Engineering Academy of Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006)
出处
《中南药学》
CAS
2019年第11期1838-1841,共4页
Central South Pharmacy
基金
广东省中医药建设专项资金项目(No.20174003)
国家重点研发计划中医药现代化专项(No.SQ2017YFC170406/01)
关键词
小叶榕
慢性支气管炎
病理切片
细胞因子
Ficus concinna Miq.
chronic bronchitis
pathological section
cell factor
