摘要
[目的]探讨止嗽散加味颗粒剂治疗气虚质流感病毒感染后咳嗽(PIC)的临床疗效.[方法]将138例气虚质流感病毒PIC患者随机分为试验组和对照组,每组各69例.对照组给予美敏伪麻溶液口服治疗,试验组在对照组的基础上给予止嗽散加味颗粒剂口服治疗,疗程均为2周.观察2组患者的咳嗽缓解时间和治疗前后咳嗽症状积分、咳嗽视觉模拟量表(VAS)评分、白细胞计数(WBC)、嗜酸性粒细胞(EO)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平的变化情况,评价2组患者的临床疗效.[结果](1)治疗2周后,试验组和对照组的总有效率分别为89.86%和72.46%,组间比较,试验组的临床总有效率高于对照组,差异有统计学意义(P<0.05).(2)试验组的咳嗽缓解时间较对照组明显缩短,差异有统计学意义(P<0.05).(3)治疗后,2组患者日间及夜间咳嗽症状积分和咳嗽VAS评分均较治疗前明显下降(P<0.05),且试验组的降低程度均明显优于对照组(P<0.05或P<0.01).(4)治疗后,试验组患者的WBC、EO、hs-CRP、TNF-α水平均较治疗前下降(P<0.05),而对照组患者仅hs-CRP、TNF-α水平较治疗前下降(P<0.05),组间比较,试验组对WBC、EO、hs-CRP、TNF-α水平的降低作用均优于对照组(P<0.05).[结论]止嗽散加味颗粒剂治疗气虚质流感病毒PIC具有较好疗效,可明显缩短患者的咳嗽缓解时间,减轻患者日间及夜间咳嗽症状,其作用可能与抑制炎症反应有关.
Objective To study the clinical effect of modified Zhisou Powder Granules in treating cough patients after influenza virus infection due to Qi deficiency constitution.Methods A total of 138 cough patients after influenza virus infection due to Qi deficiency constitution were randomly divided into control group(n=69)and trial group(n=69).The control group was given oral use of Dextromethorphan Hydrobromide Solution,and the trial group was given oral use of Dextromethorphan Hydrobromide Solution plus modified Zhisou Powder Granules.The treatment for the two groups lasted 2 weeks.Time for the relief of cough symptom was detected,and the changes in cough symptom scores,cough Visual Analogue Scale(VAS)scores,white blood cell(WBC)count,and the levels of eosinophil(EO),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factorα(TNF-α)in the two groups before and after treatment were observed.After treatment,the clinical efficacy was compared between the two groups.Results(1)After treatment for 2 weeks,the total effective rate in the trial group was 89.86%,and was higher than that in the control group(72.46%),the difference being significant(P<0.05).(2)Time for the relief of cough symptom in the trial group was much shortened as compared with that in the control group,the difference being significant(P<0.05).(3)After treatment,the scores of daytime and night-time cough symptom as well as cough VAS scores in the two groups were obviously decreased(P<0.05 compared with those before treatment),and the descent degree in the trial group was superior to that in the control group(P<0.05 or P<0.01).(4)After treatment,the levels of WBC,EO,hs-CRP,and TNF-αin the trial group as well as the levels of hs-CRP and TNF-αin the control group were obviously decreased(P<0.05 compared with those before treatment),and the decrease of WBC,EO,hs-CRP,and TNF-αin the trial group was superior to that in the control group(P<0.05).Conclusion Modified Zhisou Powder Granules exert certain effect in treating cough patients after influenza
作者
张潇双
李芳
郭永宁
ZHANG Xiao-Shuang;LI Fang;GUO Yong-Ning(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2019年第11期1698-1703,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
止嗽散加味颗粒剂
气虚质
感染后咳嗽
流感病毒
modified Zhisou Powder Granules
Qi deficiency constitution
post-infection cough
influenza virus
