摘要
[目的]观察温胆片治疗广泛性焦虑症(痰热内扰证)的临床疗效和安全性.[方法]将60例患者随机分为治疗组和对照组,每组各30例.对照组给予黛力新口服治疗,治疗组给予温胆片治疗,观察时间为6周,观察2组患者治疗前后汉密尔顿焦虑量表(HAMA)和中医证候评分的变化情况,评价2组的疗效和安全性.[结果](1)HAMA疗效:治疗6周后,治疗组的总有效率为86.7%,对照组为90.0%,2组HAMA疗效比较,差异无统计学意义(P>0.05).(2)中医证候疗效:治疗6周后,治疗组和对照组的总有效率均为90.0%,2组中医证候疗效比较,差异无统计学意义(P>0.05).(3)HAMA评分:治疗6周后,2组患者的HAMA评分均较治疗前明显下降(P<0.01),但组间比较差异无统计学意义(P>0.05).(4)中医证候总积分:治疗6周后,2组患者的中医证候总积分均较治疗前明显降低(P<0.05),且治疗组的降低作用明显优于对照组(P<0.05).(5)治疗6周后,2组患者的心烦意乱、忧虑不安、失眠或多梦等各项主症评分及治疗组患者的胸闷、心悸、口干口苦等次症评分均较治疗前降低(P<0.05),且治疗组对各项主症评分和口干口苦评分的降低作用均优于对照组(P<0.05).(6)治疗组的不良反应发生率为6.7%,对照组为33.3%,治疗组的不良反应率明显少于对照组(P<0.05).治疗期间,2组患者的肝肾功能及心电图均未见明显异常.[结论]温胆片可以改善广泛性焦虑症(痰热内扰证)患者的临床症状,是治疗广泛性焦虑症的有效方药.
Objective To evaluate the clinical efficacy and safety of Wendan Tablets in the treatment of generalized anxiety disorder with phlegm-heat disturbance syndrome.Methods A total of 60 patients were randomized into control group and treatment group,30 cases in each group.The control group was given oral use of Deanxit Tablets,and the treatment group was treated with Wendan Tablets for 6 weeks.Before and after treatment,the scores of Hamilton Anxiety Scale(HAMA)and traditional Chinese medicine(TCM)symptoms in the two groups were observed.And the clinical efficacy and safety of Wendan Tablets were evaluated.Results(1)After treatment for 6 weeks,the total effective rate for HAMA of the treatment group was 86.7%,and that of the control group was 90.0%,the difference between the two groups being insignificant(P>0.05).(2)After treatment for 6 weeks,the total effective rate for TCM symptoms of the treatment group and the control group was all 90.0%,and the difference between the two groups was insignificant(P>0.05).(3)After treatment for 6 weeks,HAMA scores of the two treatment group were obviously decreased(P<0.01 compared with those before treatment),but the difference between the two groups was insignificant after treatment(P>0.05).(4)After treatment for 6 weeks,the overall scores of TCM symptoms in the two groups were obviously decreased(P<0.05 compared with those before treatment),and the decrease in the treatment group was superior to that in the control group(P<0.05).(5)After treatment for 6 weeks,the scores of the primary symptoms of vexation,anxiety,insomnia or dreamfulness in the two groups,and the scores of secondary symptoms of chest discomfort,palpitation,dry mouth and bitterness in the mouth of the treatment group were obviously decreased(P<0.05 compared with those before treatment),and the decrease of the scores of various primary symptoms and those of the dry mouth and bitterness in the mouth of the treatment group was superior to that in the control group(P<0.05).(6)The incidence of adverse reaction in the
作者
王文秀
陈洁
荣立洋
杨忠奇
冼绍祥
WANG Wen-Xiu;CHEN Jie;RONG Li-Yang;YANG Zhong-Qi;XIAN Shao-Xiang(Sanya Hospital of Traditional Chinese Medicine,Sanya 572000 Hainan,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2019年第11期1679-1683,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家科技支撑计划项目（编号：2012BAI29B09）
广东省科技计划重大专项（编号：2012A080202018）
广东省高等学校科技创新重点项目（编号：cxzd1122）
海南省2019年卫生健康发展专项中医药专项（编号：2100601)
关键词
广泛性焦虑症
痰热内扰证
温胆片
汉密尔顿焦虑量表
中医证候评分
generalized anxiety disorder
phlegm-heat disturbance syndrome
Wendan Tablets
Hamilton Anxiety Scale
scores of traditional Chinese medicine symptoms
