摘要
组织工程作为一门新兴学科,已受到人们的广泛关注.支架材料作为组织工程的基础,必须具有好的生物相容性、可降解性和高的孔隙率才能满足组织工程的使用要求.纤维素由于其良好的生物相容性、可降解性和来源广泛,已被用于制备支架材料.然而,目前已有的纤维素膜支架材料存在孔径尺寸小、强度差和润湿性不好等缺陷.为了解决此类问题,本研究以微晶纤维素为原料,采用溶解再生-模板法制备出纤维素多孔膜,再通过复合聚乙烯醇(PVA)改善其强度和润湿性.采用SEM、XRD、FT-IR对样品形貌和结构进行表征,并测试了样品的拉伸强度.研究结果表明,采用溶解再生-模板法制备的纤维素多孔膜的孔径分别为23μm、36μm和46μm;当PVA的浓度为10%时,纤维素多孔膜的强度为2.38 MPa,比未浸渍PVA的纤维素膜强度(0.85 MPa)提高了近3倍,且润湿性得到改善.本研究扩大了纤维素膜在组织工程中的应用.
Tissue engineering as a new subject has been received extensive attention.Scaffold material as the basis of tissue engineering plays a vital role in the development of tissue engineering,which must meet the requirement with good biocompatibility and biodegradability,and high porosity.Cellulose has been used to prepare scaffold material due to its good biocompatibility,biodegradability and abundance.However,cellulose membrane scaffold materials have defects such as small pore size,low strength and poor wettability.To address these challenges,the dissolution regeneration-template method was used to prepare porous cellulose membrane.The strength and wettability of cellulose membrane are improved by PVA.The morphology and structure of the samples were characterized by SEM,XRD and FT-IR,and the tensile strength of the samples was tested.These results indicated that the cellulose membrane with pore sizes of 23μm、36μm and 46μm were prepared.Compared with porous cellulose membrane without PVA,the strength of porous cellulose/PVA membrane is 2.38 MPa when the PVA concentration is 10%,achieving 3-fold enhancement.And the wettability of cellulose membrane is improved.This study expands the application of cellulose membrane in tissue engineering.
作者
唐蕊华
刘丽娜
郑卓寅
姚雪
张素风
刘佳尧
TANG Rui-hua;LIU Li-na;ZHENG Zhuo-yin;YAO Xue;ZHANG Su-feng;LIU Jia-yao(College of Bioresources Chemical and Materials Engineering,National Demonstration Center for Experimental Light Chemistry Engineering Education,Shaanxi Province Key Laboratory of Papermaking Technology and Specialty Paper,Key Laboratory of Paper Based Functional Materials of China National Light Industry,Shaanxi University of Science&Technology,Xi′an 710021,China;School of Life Science and Technology,The Key Laboratory of Biomedical Information Engineering of Ministry of Education,Bioinspired Engineering and Biomechanics Center(BEBC),Xi′an Jiaotong University,Xi′an 710049,China)
出处
《陕西科技大学学报》
CAS
2019年第6期99-104,共6页
Journal of Shaanxi University of Science & Technology
基金
陕西省科技厅自然科学基础研究计划项目(2019JQ-517)
陕西省教育厅专项科研计划项目(18JK0096)
国家级大学生创新创业训练计划项目(201910708001)
陕西科技大学轻化工程国家级实验教学示范中心开放课题(2018QGSJ02-10)
关键词
纤维素
孔结构
支架材料
cellulose
pore structure
scaffold materials
