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基于JAK-STAT信号通路的药物研究进展 被引量:24

Progress in drugs research based on JAK-STAT signaling pathway
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摘要 细胞之间的通信参与调节细胞增殖、成熟、分化以及凋亡等生命活动,当细胞之间通信出现异常可导致代谢紊乱、免疫失控、肿瘤等多种疾病.JAK-STAT(Janus kinase-signal transducer and activator of transcription)信号通路是一组古老的信号通路,许多细胞因子包括白介素、干扰素、粒细胞/巨噬细胞集落刺激因子、红细胞生成素以及促血小板生成素等均通过该信号通路传导信号.研究表明,JAK-STAT通路与红细胞增多症、血小板增多症、白血病以及骨髓纤维化等血液相关疾病和类风湿关节炎、强直脊柱炎、红斑狼疮、牛皮癣等自身免疫疾病的发生息息相关.因此,JAK-STAT信号通路成为多种血液性疾病和自身免疫疾病的重要靶点.本文将从JAK-STAT信号通路的原理、临床意义、药物开发进展等多个方面对其进行阐述. Communications between cells is involved in regulating life activities such as cell proliferation,maturation,differentiation,and apoptosis.When abnormal communication occurs between cells,metabolic disorders,immune disorders and tumors can be caused.Signals of many cytokines including interleukins,interferons,granulocyte/macrophage colony-stimulating factor,erythropoietin and thrombocytopenia are conducted by an ancient signaling pathway called the JAK-STAT(Janus kinase-signal transducer and activator of transcription)signaling pathway.Studies have shown that the JAK-STAT pathway is closely related to blood diseases such as erythrocytosis,thrombocytosis,leukemia and bone marrow fibrosis,and autoimmune diseases such as rheumatoid arthritis,ankylosing spondylitis,lupus erythematosus and psoriasis.Therefore,the JAK-STAT signaling pathway has become an important target for a variety of blood diseases and autoimmune diseases.This article will elaborate on the principle,clinical significance and progress of drug development of JAK-STAT signaling pathway.
作者 王学川 李霄 梁承远 WANG Xue-chuan;LI Xiao;LIANG Cheng-yuan(College of Bioresources Chemical and Materials Engineering,National Demonstration Center for Experimental Light Chemistry Engineering Education,Shaanxi University of Science&Technology,Xi′an 710021,China;School of Food and Biological Engineering,Shaanxi University of Science&Technology,Xi′an 710021,China)
出处 《陕西科技大学学报》 CAS 2019年第6期79-86,共8页 Journal of Shaanxi University of Science & Technology
基金 国家自然科学基金项目(81602967) 中国博士后科学基金项目(2016M592898XB)
关键词 JAK-STAT 血液疾病 自身免疫疾病 JAK-STAT blood disease autoimmune disease
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