摘要
动脉粥样硬化(atherosclerosis,AS)是一个复杂的病理过程,涉及脂质积累、内皮受损、单核/巨噬细胞吞噬、泡沫样细胞形成、平滑肌细胞迁移、胶原纤维堆积、炎症反应等复杂机制[1-3]。研究表明,超过一半的心血管疾病(包括AS等)均与遗传有着密不可分的联系[4-5]。
Atherosclerosis(AS) is a common cardiovascular disease and a major cause of coronary heart di-sease, cerebral infarction and peripheral vascular disease. Circular RNA(circRNA) is a class of circularly closed non-co-ding RNAs that play an important role in the formation of AS. Physiological and pathological significances of the processes such as lipid metabolism, endothelial cell damage, vascular smooth muscle cell proliferation and migration, monocyte pha-gocytosis and foam-like cell formation, and inflammatory responses are involved in the development of AS. Most circRNA adjust mRNA expression by regulating microRNAs(miRNAs). circRNA provides new ideas and targets for the diagnosis and treatment of AS.
作者
黄鹏
徐瑞
娄小倩
谭琦
任立群
HUANG Peng;XU Rui;LOU Xiao-qian;TAN Qi;REN Li-qun(College of Pharmacy,Jilin University,Changchun 130000,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2019年第11期2098-2102,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81773934)
