摘要
目的:观察荜茇宁对实验性动脉粥样硬化(AS)家兔抗氧化酶类活性的影响。方法:以高脂饲料喂养家兔建立AS模型,给予高脂饲料的同时给予荜茇宁,连续60d。检测血清、肝脏和主动脉组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)的活性和丙二醛(MDA)含量,并且测定血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的含量,计算各组兔主动脉粥样硬化斑块面积比。结果:荜茇宁能提高AS家兔SOD、CAT、GSH-Px的活性(P<0.05),降低MDA(P<0.05),并且降低血清TC和LDL-C水平和主动脉斑块面积比(P<0.05)。结论:荜茇宁具有增强抗氧化酶活性、调节血脂作用,可预防动脉粥样硬化的发生。
Aim：To observe the effect of piperlonguminine on the anti-oxidase activities in experimental athemsclemsis rabbits. Methods：The atherosclerosis model rabbits were induced by feeding with the high-lipid diet for 60 days, during which feeding was accompanied by oral administration of piperlonguminine to the rabbits. Then the activities of supemxide dismutase（SOD）, catalase （CAT）and glutathione pemxidase （GSH-Px）, as well as and the contents of malondialdehyde （MDA） in serum, liver and aorta were assayed.The contents of serum total cholesterol （TC）, lowdensity lipopmtein cholesterol （LDL-C） of rabbits in each of the groups were determined, and the area of rabbit aorta suffering from atheresclemsis plaque was measured. Results： Piperlonguminine increased the activities of SOD, CAT and GSH-Px （ P 〈 0.05） ; reduced the content of MDA （ P 〈 0.05） ; and significantly lowered the sermn contents of TC and LDL-C as well as the area of lipid-plaqued aorta endothelium of rabbits （P 〈 0.05）. Conclusion： Piperlongumi- nine could enhance the activities of anti-oxidase and modulate the serum lipid level, and it prevents the development of atherosclemsis in the model.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2008年第1期68-71,共4页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目(No30160103)~~
