摘要
目的分析H型高血压患者血清非对称性二甲基精氨酸(ADMA)、同型半胱氨酸(Hcy)、白介素-6(IL-6)水平与脂质代谢及颈动脉内膜中层厚度(IMT)的关系。方法选取2016年1月-2018年12月内蒙古医科大学附属医院老年医学中心一病区治疗的高血压患者100例为研究对象,根据高血压患者血清Hcy水平分为H型高血压组(n=43)和非H型高血压组(n=57),另选同期在医院进行体检的健康志愿者50例为健康对照组。比较各组血清ADMA、Hcy、IL-6、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)水平及IMT、ApoB/ApoA1比值,采用Pearson法分析H型高血压患者ADMA、Hcy、IL-6水平与LDL-C、HDL-C、ApoB、ApoA1、ApoB/ApoA1比值、IMT的相关性,采用多因素Logistic回归分析H型高血压发病的影响因素。结果H型高血压组患者的ADMA、Hcy、IL-6、TG、TC、LDL-C、ApoB、ApoB/ApoA1、IMT均高于非H型高血压组和健康对照组(F=227.382、193.151、191.308、108.244、84.074、63.034、155.234、160.809、61.550,P均=0.000),HDL-C、ApoA1水平均低于非H型高血压组和健康对照组(F=71.983、15.753,P均=0.000)。经Pearson相关性分析,H型高血压患者的ADMA、Hcy、IL-6与TG、TC、LDL-C、ApoB、ApoB/ApoA1、IMT呈正相关(r均在0.432~0.562内,P均<0.01),与HDL-C、ApoA1呈负相关(r均在-0.513^-0.471内,P均<0.01)。经多因素Logistic回归分析,ADMA、Hcy、IL-6、ApoB、ApoB/ApoA1、IMT均可能是H型高血压的危险影响因素(OR=1.654~2.731,P均<0.01)。结论H型高血压患者血清ADMA、Hcy、IL-6水平变化与脂质代谢及IMT有关联,对上述指标进行监测对于H型高血压的治疗预防有重要意义。
Objective Analysis of serum asymmetric dimethylarginine(ADMA),homocysteine(Hcy),interleukin-6(IL-6)levels and lipid metabolism and carotid intima-media thickness(IMT)in patients with type H hypertension relationship.Methods From January 2016 to December 2018,100 patients with hypertension treated in a ward of geriatric medical center,Affiliated Hospital of Inner Mongolia Medical University were selected as the study object.According to the serum Hcy level of hypertension patients,they were divided into H-type hypertension group(n=43)and non-h-type hypertension group(n=57).Another 50 healthy volunteers were selected as the control group.The levels of ADMA,Hcy,IL-6,TG,TC,LDL-C,HDL-C,apoB,ApoA1 and the ratio of IMT,apoB/ApoA1 were compared.Pearson's method was used to analyze the correlation between ADMA,Hcy,IL-6 and LDL-C,HDL-C,apoB,ApoA1,apoB/ApoA1 ratio,IMT.Multivariate logistic regression was used to analyze the influencing factors of H-type hypertension.Results Patients with H-type hypertension had higher levels of ADMA,Hcy,IL-6,TG,TC,LDL-C,ApoB,ApoB/ApoA1,and IMT than non-H-type hypertension group and healthy control group(F=227.382,193.151,191.308,108.244,84.074,63.034,155.234,160.809,61.550,P=0.000).The levels of HDL-C and ApoA1 were lower than those of non-H type hypertension group and healthy control group(F=71.983,15.753,P=0.000).According to Pearson correlation analysis,ADMA,Hcy and IL-6 were positively correlated with TG,TC,LDL-C,ApoB,ApoB/ApoA1 and IMT in H-type hypertensive patients(r were all within 0.432~0.562,P<0.01).It was negatively correlated with HDL-C and ApoA1(r was within-0.513 to-0.471,P<0.01).After multivariate logistic regression analysis,ADMA,Hcy,IL-6,ApoB,ApoB/ApoA1,and IMT were all risk factors for H-type hypertension(OR=1.654~2.731,P<0.01).Conclusion The changes of serum ADMA,Hcy and IL-6 levels in patients with H-type hypertension are related to lipid metabolism and IMT.Monitoring the above indicators is of great significance for the treatment and prevention of H-type hypertension.
作者
包秋红
贾海玉
曹中朝
张强
刘滨松
BAO Qiuhong;JIA Haiyu;CAO Zhongchao;ZHANG Qiang;LIU Binsong(First Ward of Geriatric Medical Center,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia,Hohhot 010050,China)
出处
《疑难病杂志》
CAS
2019年第11期1094-1098,共5页
Chinese Journal of Difficult and Complicated Cases
基金
内蒙古医科大学青年创新基金项目(YKD2016QNCX026)
