摘要
目的分析围绝经期妇女性激素变化和血脂指标变化的关系,为围绝经妇女保健提供指导。方法 2010年10月—2011年9月收集了张家港市妇幼保健所门诊402例40～65岁妇女,按月经情况分为绝经前期、绝经期、绝经后期三组,分别测定其血清性激素促卵泡生成素(FSH)、雌二醇(E2),血脂指标甘油三酯(TG)、血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。利用统计学方法分析三组间性激素及血脂变化情况。结果三组妇女中FSH水平在绝经期组和绝经后期组妇女中显著增高(P<0.05),E2水平在绝经期组和绝经后期组妇女中不同程度降低,以绝经后期组显著(P<0.05)。三组妇女的血脂指标TG、TC和LDL-C逐渐增高(P<0.05),HDL-C的变化三组间不显著。结论围绝经妇女卵巢功能减退首先表现为FSH的增高,E2水平的降低相对滞后。随着雌激素水平下降血脂TG、TC、LDL-C明显增高。
Objective To investigate the relationship between serum sexual hormones levels and blood lipid of perimenopause women, and to provide guidance for healthcare of perimenopause women. Methods 402 cases of perimenopause women （40 - 65 years old） were assigned into three groups according to menstrual：premenopause group, perimenopause group and postmenopause group. The serum levels of estradiol （ E2 ） , follicle timulating hormone （FSH） , Triglyceride （TG） , serum total, cholesterol （ TC ） , high-density lipoproteineholesterol （HDL-C） and low-density lipoprotein cholesterol（LDL-C） were detected. Statistical method were used to analyze the condition of sex hor- mone and blood lipid among three groups. Results FSH is significantly higher in perimenopause group and postmenopause group. There were significant differences among three groups （ P 〈 0.05 ）. The serum levels of estradiol descended to different degree among the groups, but there was a significant decrease in postmenopause group （ P 〈 0.05 ）. Among three groups the TG, TC and LDL-C were in- creased gradually （ P 〈 0.05 ）. There were no obvious changes about HDL-C. Conclusion With the decrease of estradiol, the TG, TC and LDL-C elevate significantly.
出处
《安徽医药》
CAS
2013年第4期590-591,共2页
Anhui Medical and Pharmaceutical Journal
关键词
围绝经妇女
性激素
血脂
perimenopause women
sex hormone
blood lipid
