摘要
目的:分析行体外受精/卵胞浆内单精子显微注射(IVF/ICSI)的25岁及以下女性的助孕特征及结局。方法:回顾性分析第一周期行IVF/ICSI助孕的12 350例患者的临床资料,其中女性年龄20~岁522例,23~岁3 030例,26~30岁8 798例。比较3个年龄组患者的临床特征、助孕过程及妊娠结局。结果:3组不孕年限、男性因素不孕者占比、促性腺激素(Gn)用量和使用时间、HCG日雌二醇水平、ICSI占比差异均有统计学意义(P<0.05)。20~岁组、23~岁组促性腺激素(Gn)用量和使用时间均小于26~30岁组(P<0.05),20~岁组男性因素不孕者占比、HCG日雌二醇水平、ICSI占比大于26~30岁组(P<0.05);23~岁组单个取卵周期活产率低于26~30岁组,全部周期累积活产率高于26~30岁组(P<0.05)。精子来源为丈夫射出且受精方式为IVF人群3组间单个取卵周期活产率和全部周期累积活产率差异无统计学意义(P>0.05)。结论:IVF/ICSI助孕时,20~岁、23~岁及26~30岁女性生育能力基本相同。
Aim:To analyze the outcome of women(≤25 years)received in vitro fertilization/introcytoplasmatic single sperm injection(IVF/ICSI)and their characteristics.Methods:A retrospective study was executed.A total of 12 350 women who received first cycle of IVF/ICSI were enrolled,522 cases were 20-years old(Group A),3 030 cases were 23-years old(Group B),and 8 798 cased were 26-30 years old(Group C).Clinical characteristics,course and outcomes of IVF/ICSI in different groups were compared.Results:There were significant differences in infertility time,the proportion of males factors in infertility course,gonadotropin(Gn)dosage and time,the estrogens(E2)level on HCG day,and the proportion of ICSI among the 3 groups(P<0.05).The Gn dosage and time of Group A and B were lower than those of Group C(P<0.05).The proportion of males factors in infertility course,E2 level on HCG day,and the proportion of ICSI of Group A were higher than those of Group C(P<0.05).Compared with Group C,Group A had lower rate of live-birth rate and higher cumulative live-birth rate(P<0.05).The live-birth rate and cumulative live-birth rate were similar in three groups when only considering the women who accepted IVF with the sperm ejaculated from husband.Conclusion:Fertility of women aged 20-years,23-years and 26-30 years are similar during IVF/ICSI.
作者
孔慧娟
卜志勤
王芳
苏迎春
KONG Huijuan;BU Zhiqin;WANG Fang;SU Yingchun(Center for Reproductive Medicine,the First Affiliated Hospital,Zhengzhou University,Henan Key Laboratory of Reproduction and Genetics,Zhengzhou 450052)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2019年第5期775-779,共5页
Journal of Zhengzhou University(Medical Sciences)
关键词
体外受精
胚胎移植
超排卵
妊娠结局
女性年龄
fertilization in vitro
embryo transfer
controlled ovarian hyperstimulation
pregnancy outcome
the female age
