摘要
目的系统评价高纯度人尿促卵泡素应用于超促排卵周期的临床疗效。方法计算机检索Pub Med、The Cochrane Library(2014年第7期)、Web of Science、EMBase、中国生物医学文献数据库、中国知网、维普和万方数据库,检索时限为从建库至2014年7月。收集试验组采用高纯度人尿促卵泡素进行超促排卵治疗,对照组采用基因重组促卵泡素进行超促排卵治疗的随机对照试验(RCT)或临床对照试验(CCT)。对纳入文献进行质量评价和数据提取,采用Rev Man 5.2软件对两组临床妊娠率、活产率、成熟卵数、获卵数、超促排卵刺激天数进行分析。结果共纳入10篇RCT,4 784例患者。两组临床妊娠率、活产率、成熟卵数、获卵数、超促排卵刺激天数比较,差异均无统计学意义〔OR=1.01,95%CI(0.90,1.14),P=0.83;OR=1.04,95%CI(0.91,1.19),P=0.56;MD=-0.21,95%CI(-0.80,0.38),P=0.49;MD=-0.12,95%CI(-0.82,0.58),P=0.73;MD=-0.40,95%CI(-0.91,0.11),P=0.12〕。敏感性分析结果显示,两组获卵数和超促排卵刺激天数与原结果基本一致,具有较好的稳定性。漏斗图左右呈大致对称,存在发表偏倚的可能性较小。结论高纯度人尿促卵泡素在超促排卵周期中的临床疗效与基因重组促卵泡素相当。但由于受纳入文献数量和质量的限制,有待开展更多高质量、多中心研究加以验证。
Objective To systematically review the clinical efficacy of high-purity follicle-stimulating hormone in the cycle of controlled ovarian hyperstimulation（ COH）. Methods We made computer retrieval from Pub Med,The Cochrane Library（ Issue 7,2014）,Web of Science,EMBase,CBM,CNKI,VIP and Wanfang Data. The searching time range was set from database establishment to July 2014. Through the retrieval,we collected literatures about randomized controlled studies（ RCT） or clinical controlled trical（ CCT） which the trial group was administrated with COH by using high-purity follicle-stimulating hormone and the control group was administrated with COH by using genetically recombined follicle-stimulating hormone. Qualify evaluation and data extraction were conducted on the included literatures. Rev Man 5. 2 software was used to analyze clinical pregnancy rate,live birth rate,the number of mature ovums,the number of retrieved oocytes and the number of COH days. Results We included 10 pieces of RCT literatures, concerning with 4 784 patients. The two groups were not significantly different in clinical pregnancy rate,live birth rate,the number of mature ovums,the number of retrieved oocytes and the number of COH days 〔OR = 1. 01,95% CI（ 0. 90,1. 14）,P = 0. 83; OR = 1. 04,95% CI（ 0. 91,1. 19）,P =0. 56; MD =-0. 21,95% CI（-0. 80,0. 38）,P = 0. 49; MD =-0. 12,95% CI（-0. 82,0. 58）,P = 0. 73; MD =-0. 40,95% CI（-0. 91,0. 11）,P = 0. 12 〕. The sensitivity analysis showed that the number of retrieved oocytes and the number of COH days of the two groups were basically the same with original results,which indicated good stability. The funnel plot was generally symmetrical on two sides, indicating small possibility in publication bias. Conclusion Compared with genetically recombined follicle-stimulating hormone,high-purity follicle-stimulating hormone has same efficacy in the cycle of COH. However,due to the limited number and quality of included literatures,more high-quality and multi-center researches ne
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第29期3613-3618,共6页
Chinese General Practice
基金
新疆维吾尔自治区自然科学基金资助项目(2013211A087)
关键词
促卵泡素
人尿
体外受精
胚胎移植
超排卵
META分析
随机对照试验
Follicle-stimulating hormone
human urine
In vitro fertilization
Embryo transfer
Superovulation
Meta-analysis
Randomized controlled trial
