摘要
间充质干细胞 (mesenchymalstemcell,MSC)具有向成骨细胞、成软骨细胞、脂肪细胞及成肌细胞分化的多向潜能 ,可在造血微环境形成、组织修复及基因治疗中得到应用。多种生长因子如TGF β,IGF Ⅰ ,BMP及FGF在MSC分化中发挥不同的促进作用并有协同性 ;MSC可分泌G CSF ,SCF ,LIF ,M CSF ,IL 6和IL 1 1等多种细胞因子支持造血并与某些疾病的发生有关 ;相关因子作用后的MSC将在基因工程应用中发挥重要作用。
Mesenchymal stem cells possess the ability to differentiate into osteoblasts, chondroblasts, lipoblasts, myoblasts and so on, which can be used in the formation of hematopoietic microenvironment, tissue repairing and gene therapy. Growth factors such as TGF β, IGF Ⅰ, BMP and FGF can influence on the differentiation of MSC and they cooperate with each other. MSC support hematopoiesis by secreting cytokines including G CSF, SCF, LIF, M CSF, IL 6 , IL 11 and are related to some diseases. MSC would demonstrate important effect on gene engineering.
出处
《中国实验血液学杂志》
CAS
CSCD
2002年第5期468-471,共4页
Journal of Experimental Hematology
基金
"973"国家重点基础研究发展规划资助项目(编号G19990 54 2 0 5)
全军"十五"医药卫生科研青年基金资助项目(编号OlQll0 )
