摘要
目的研究血清胱抑素C对类风湿关节炎(rheumatoid arthritis,RA)心血管疾病(cardiovascular disease,CVD)患者的影响。方法选取2015年1月至2017年12月在揭阳市人民医院住院的RA患者160例,根据患者是否合并心血管病变,分为RA合并CVD组(n=80)及RA未合并CVD组(n=80)。选取健康对照者80名作为正常对照组。分别检测3组患者的血清胱抑素C、胆固醇及三酰甘油浓度,同时记录所有研究对象的年龄、病程、体质量、是否合并原发性高血压(高血压),测定RA患者类风湿因子(rheumatoid factor,RF)、抗环瓜氨酸肽抗体(cyclic citrullinated peptide antibody,ACCP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、C-反应蛋白(C-reactive protein,CRP)、同型半胱氨酸、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白A(immunoglobulin A,IgA)等相关指标,分析RA未合并CVD组、RA合并CVD组及正常对照组胱抑素C浓度的差异,以及胱抑素C与各项指标之间的相关性。结果RA患者血清胱抑素C浓度高于正常对照组,RA合并CVD组血清胱抑素C浓度高于RA未合并CVD组,差异具有统计学意义(P<0.05)。RA合并CVD患者血清胱抑素C浓度与CRP、同型半胱氨酸、RF、IgM、IgA浓度呈正相关(P<0.05)。胱抑素C浓度≥2mg/L时,RF、CRP、IgA、IgM、同型半胱氨酸浓度均高于胱抑素C浓度<2mg/L时,差异具有统计学意义(P<0.05)。结论血清胱抑素C浓度与RA疾病活动度及CVD发生密切相关。通过对RA患者血清胱抑素C浓度的检测,能更好地预测RA合并CVD的发生。
Objectives To study the effect of serum cystatin C in patients with rheumatoid arthritis(RA)and cardiovascular disease(CVD).Methods A total of 160 patients with RA were enrolled in The People′s Hospital of Jieyang from January 2015 to December 2017.All patients were divided into RA with CVD group(n=80)and RA without CVD group(n=80)according to whether or not associated with CVD.In the same period,80 normal subjects were selected as control group.Concentrations of cystatin C,cholesterol and triglycerides in the three groups were tested and age, course of disease,weight,hypertension were recorded in all cases.Concentrations of rheumatoid factor(RF),anti cyclic citrullinated peptide antibody(ACCP),C-reactive protein(CRP),homocysteine,immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)and erythrocyte sedimentation rate(ESR)were tested in RA patients.The differences of cystatin C in RA with CVD group,RA without CVD group and control group were analyzed,and the correlations between cystatin C and various indexes were analyzed.Results Concentration of cystatin C in patients with RA was significantly higher than that in control group(P<0.05).Concentration of cystatin C in RA with CVD group was higher than that in RA without CVD group,with statistical differences(P<0.05).Concentration of cystatin C in RA with CVD group positively correlated with CRP,homocysteine,RF,IgM and IgA(P<0.05).Concentrations of RF,CRP,IgA,IgM and homocysteine in patients with cystatin C≥2 mg/L were significantly higher than those in patients with cystatin C<2 mg/L(P<0.05).Conclusions Concentration of cystatin C closely relates with disease activity and CVD in patients with RA,which might be an effective predictor of CVD.
作者
薛晓倩
江洪耿
许百洁
钟晓泽
薛文昌
莫守崎
XUE Xiao-qian;JIANG Hong-gen;XU Bai-jie;ZHONG Xiao-ze;XUE Wen-chang;MO Shou-qi(Division of Rheumatology and Nephrology,The People′s Hospital of Jieyang,Guangdong ,Jieyang 522000 China;Division of Orthopaedics,The People′s Hospital of Jieyang,Jieyang,Guangdong 522000,China;Depart. ment of Dermatology,Chronic Disease Prevention and Control in Rongcheng,Jieyang,Guangdong 522000,China)
出处
《岭南心血管病杂志》
2019年第5期556-560,共5页
South China Journal of Cardiovascular Diseases
基金
揭阳市医学科学技术研究项目
关键词
胱抑素C
类风湿关节炎
心血管病变
cystatin C,rheumatoid arthritis
cardiovascular disease
