摘要
目的:探讨中性粒细胞与淋巴细胞比值(NLR)在类风湿关节炎(RA)诊断中的临床价值。方法:选取在我院确诊RA患者148例、非RA风湿病患者135例(结缔组织病、强直性脊柱炎、骨关节炎、系统性红斑狼疮、干燥综合征)、健康体检者138名,检测3组中性粒细胞、淋巴细胞、红细胞体积分布宽度、超敏C反应蛋白(CRP)和血沉,且计算NLR数值,进行统计学分析比较;通过Spearman相关分析及多元线性回归分析探讨NLR与其他指标关系;ROC曲线比较各指标的诊断性能。结果:RA患者及非RA自身免疫疾病患者NLR值均显著高于健康对照组(P<0.05);Spearman相关分析显示RA患者NLR与WBC、NC、LC、CRP相关性显著(P≤0.01),多元线性回归分析显示NLR也与以上指标相关,标准化系数为-0.767(P<0.05);ROC曲线分析显示,NLR诊断RA的AUC值为0.741,敏感度为73.0%,特异性为65.2%,同时显示ACCP诊断RA的特异性最高。结论:NLR可作为一种新的炎症反应指标对RA的诊断及疗效观察具有一定的价值。
Objective: To investigate the clinical value of neutrophil to lymphocyte ratio(NLR) in the diagnosis of rheumatoid arthritis (RA). Methods: One hundred and forty-eight RA patients and 135 non-RA Rheumatic diseases (connective tissue disease, ankylosing spondylitis, osteoarthritis, systemic lupus erythematosus, Sjogren’s syndrome) patients and 138 healthy people were selected and tested for neutrophils, lymphocytes, red blood cell volume distribution width and hypersensitive C-reactive protein(CRP). The relationship between NLR and other indexes was studied by Spearman correlation analysis and multiple linear regression analysis, and the diagnostic performance of each index was compared by ROC curve. Results: The NLR values of RA patients and non-RA patients with autoimmune diseases were significantly higher than those of healthy controls (P<0.05);Spearman correlation analysis showed that NLR of RA patients was significantly correlated with WBC, NC, LC and CRP(P<0.01), and multiple linear regression analysis showed that NLR was also correlated with the above indexes, and the standardization coefficient was -0.767(P<0.05). ROC curve analysis showed that the AUC value of NLR in diagnosis of RA was 0.741, sensitivity was 73.0%, specificity was 65.2%, and ACCP had the highest specificity in diagnosis of RA. Conclusion: NLR can be used as a new index for inflammatory response and may have certain value in the diagnosis and effect observation of RA.
作者
刘勤
张学军
岳超
LIU Qin;ZHANG Xue-jun;YUE Chao(Department of Immunology,School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China;Department of Clinical Laboratory,Tianjin Fifth Central Hospital,Tianjin 300450,China;Department of Blood Transfusion,Tianjin Fifth Central Hospital,Tianjin 300450,China)
出处
《天津医科大学学报》
2019年第4期366-368,377,共4页
Journal of Tianjin Medical University
关键词
类风湿关节炎
中性粒细胞与淋巴细胞比值
超敏C反应蛋白
血沉
类风湿因子
rheumatoid arthritis
neutrophil to lymphocyte ratio
hypersensitive C-reactive protein
erythrocyte sedimentation rate
rheumatoid factor
