摘要
目的探讨川芎嗪联合酚妥拉明治疗慢性肺源性心脏病合并心力衰竭的临床效果。方法选取南乐县人民医院2017年9月至2018年8月收治的102例慢性肺源性心脏病合并心力衰竭患者,采用随机数表法分为对照组和观察组,每组51例。在常规治疗基础上,对照组患者静脉滴注酚妥拉明,观察组患者在对照组基础上静脉滴注川芎嗪。两组均持续治疗2周。比较两组治疗总有效率、心功能、症状缓解时间。结果对照组和观察组治疗总有效率分别为72.55%(37/51)、92.16%(47/51)。观察组治疗总有效率较对照组高,差异有统计学意义(P<0.05)。治疗2周后,观察组LVEF高于对照组,LVEDD、LVESD低于对照组,差异有统计学意义(均P<0.05)。观察组患者心慌气短、肺湿啰音、下肢水肿缓解时间均较对照组短,差异有统计学意义(均P<0.05)。结论川芎嗪联合酚妥拉明可有效提高慢性肺源性心脏病合并心力衰竭治疗效果,改善患者心功能,加速症状缓解。
Objective To investigate the effects of ligustrazine combined with phentolamine in the treatment of chronic pulmonary heart disease complicated with heart failure.Methods A total of 102 patients with chronic pulmonary heart disease complicated with heart failure who were admitted to the Nanle County People’s Hospital from September 2017 to August 2018 were randomly divided into control group and observation group, with 51 cases in each group. On the basis of conventional treatment, control group received intravenous infusion of phentolamine, and observation group received intravenous infusion of ligustrazine on the basis of control group. The treatment lasted for 2 weeks. The total effective rate, cardiac function, and symptom relief time of the two groups were compared.Results The total effective rates of control group and observation group were 72.55%(37/51) and 92.16%(47/51), respectively. The total effective rate of observation group was higher than that of control group, and the difference was statistically significant(P<0.05). After 2 weeks of treatment, the LVEF of observation group was higher than that of control group, LVEDD and LVESD were lower than control group, and the differences were statistically significant(all P<0.05). The flusteredness, moist rales, and lower extremity edema in observation group all alleviated faster than those in control group, and the differences were statistically significant(all P<0.05).Conclusion Ligustrazine combined with phentolamine could effectively improve the efficacy of chronic pulmonary heart disease complicated with heart failure, improve the heart function of patients and accelerate the relief of symptoms.
作者
韩现志
丁进京
李晖
Han Xianzhi;Ding Jinjing;Li Hui(Internal Medicine Department,Nanle County People's Hospital,Puyang 457400,China;Hospital office Nanle County People’s Hospital,Puyang 457400,China)
出处
《中华心脏与心律电子杂志》
2019年第4期226-228,共3页
Chinese Journal of Heart and Heart Rhythm(Electronic Edition)
