摘要
目的探讨胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ水平变化结合智能分光比色(FICE)放大内镜对胃癌前病变(PLGC)及胃癌(GC)诊断的价值。方法应用酶联免疫法测定了568名胃部疾病患者及120名健康受检者血清PGⅠ、PGⅡ、PGⅠ/PGⅡ水平。并将568例患者随机分为2组(FICE放大内镜组和普通白光内镜组),各284例。FICE放大内镜组于FICE放大模式下进行观察,并在可疑病灶处活检;普通白光内镜组按肉眼判断常规活检。比较2组阳性检出率情况,并比较各种不同胃部疾病患者及健康受检者血清PGⅠ、PGⅡ水平。结果与正常组相比较,慢性浅表性胃炎(CSG)不伴肠上皮化生(IM)及异型增生(Dys)患者、胃溃疡(GU)患者,血清PGⅠ、PGR水平显著升高(P <0. 05),CSG伴IM及Dys患者、CAG患者、早期GC患者及GC患者血清PGⅠ、PGR水平显著降低(P <0. 05)。FICE放大内镜组阳性检出率85. 2%,普通白光内镜组阳性检出率53. 2%,2组阳性检出率差异有统计学意义(χ^2=68. 39,P <0. 05)。结论血清PGⅠ、PGⅡ、PGR可作为PLGC及GC筛查的一项血清学指标,结合FICE放大内镜技术,可以显著提高PLGC及GC的诊断率。
Objective To study the pepsinogen( PG)Ⅰ,PG Ⅱ,PG Ⅰ intelligent spectral color change/PG Ⅱ levels( FICE) magnification endoscopy of lesion before cancer of the stomach( PLGC) and the value of the diagnosis of gastric cancer( GC). Methods Enzyme-linked immunoassay method for the determination of the 568 patients with abdominal discomfort and120 healthy subjects serum PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ level,and 568 patients were randomly divided into two groups( FICE magnifying endoscopy and ordinary white light endoscopy group) and 284 cases in each group,FICE magnifying endoscopy group in FICE amplification mode in suspicious lesion biopsy,the control group does not make the judgment to the naked eye the routine biopsy,compared two groups of positive detection rate,and compare the different stomach diseases patients and healthy subjects serum PGⅠ、PGⅡ level. Results Compared with normal group,chronic superficial gastritis( CSG) is not associated with intestinal metaplasia( IM) and hyperplasia( Dys) patients,patients with gastric ulcer( GU),serum PG Ⅰ,PGR levels increased significantly( P < 0. 05),patients with IM and Dys with CSG,the CAG,early GC and GC group serum PG Ⅰ,PGR levels lower( P< 0. 05). FICE magnification endoscopy group positive detection rate 85. 2%;Ordinary white light endoscopy group of positive detection rate of 53. 2%. The positive detection rate similar between the two groups was statistically significant( P < 0. 05). Conclusion PG Ⅰ,PG Ⅱ,PGR can be used as a serological PLGC and GC screening indicators,combined the technology of FICE magnifying endoscopy,Diagnosis of PLGC and GC can be improved significantly.
作者
陈艳红
胡俊
李志晋
吴淑芬
CHEN Yanhong;HU Jun;LI Zhijin(NO. 908 Hospital of Joint Logistics Units of the PLA,Yingtan,335000)
出处
《实用癌症杂志》
2019年第10期1677-1679,共3页
The Practical Journal of Cancer
关键词
胃蛋白酶原
内镜智能分光比色技术
胃癌
胃癌前病变
Pepsinogen
Fuji intelligent chromo endoscopy
Gastric carcinoma
Precancerous lesions gastric cancer
