摘要
目的:探讨根除幽门螺杆菌(helicobacter pylori,HP)感染对胃黏膜炎症和肠腺化生(intestinal meta-plasia,IM)的意义。方法:随访119例10年前HP感染的患者,其中62例行根除HP治疗(治疗组),57例中断治疗或仅接受对症治疗(对照组),对比其前后HP感染情况、胃黏膜炎症及肠腺化生(IM)的变化情况。结果:10年后对照组中45/57例HP呈阳性(78.94%);治疗组中15例HP呈阳性(24.19%),胃炎活动性检出率明显减少与对照组持续HP感染者比较,差异有显著性(P<0.01),肠腺化生(IM)的程度也显著减轻(P<0.05)。结论:HP感染与胃黏膜活动性炎症关系非常密切,根除HP可以减轻胃黏膜的炎症和肠腺化生(IM)程度。
Objective：To investigate the effect of Helicobacter pylori（HP） eradication on the inflammation and intestinal metaplasia in gastric mucosa.Methods： One hundred and seventeen patients with HP infection were selected,including 62 cases of HP eradication therapy（treatment group）,57 patients discontinued treatment or received only symptomatic treatment（control group）.All patients were followed up for 10 years.HP infection,inflammation and intestinal metaplasia in gastric mucosa were detected before and after HP eradication.Results： During the ten-year follow-up,the number of patients who continued to be positive for Hp was 45（78.94%） in control group,and 15（24.19%） in treatment group,respectively.The severity and activity of inflammation in gastric mucosa were significantly reduced（P0.01）,and the proportion of intestinal metaplasia in gastric mucosa was significantly reduced（P0.05） in treatment group,compared with control group.Conclusion： HP infection is related to the activity of chronic gastritis,and HP eradication may reduce the degree of inflammation and intestinal metaplasia in gastric mucosa.
出处
《现代肿瘤医学》
CAS
2011年第9期1825-1826,共2页
Journal of Modern Oncology
关键词
幽门螺杆菌
胃炎
肠腺化生
helicobacter pylori
gastritis
intestinal metaplasia
