摘要
目的探讨阿尔茨海默病(AD)和血管性痴呆(VD)患者血清炎症因子和生化指标的检测及临床意义。方法选取2014年7月至2016年7月该院收治的AD患者50例作为AD组,VD患者50例作为VD组。另选取同期来该院体检的50例健康人群作为健康对照组,对血清中各类炎症因子进行比较,分别对3组研究对象各项指标进行分析。结果AD组与VD组三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)水平均明显高于健康对照组,差异均有统计学意义(P<0.05),VD组尤其明显;AD组与VD组TG、LDLC、TC水平比较,差异均无统计学意义(P>0.05);3组血清HDL-C水平比较差异均无统计学意义(P>0.05)。AD组血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)及白细胞介素-6(IL-6)水平均明显高于VD组和健康对照组,差异均有统计学意义(P<0.05);VD组IL-6及TNF-α水平与健康对照组比较,差异均无统计学意义(P>0.05),但CRP明显高于健康对照组,差异有统计学意义(P<0.05)。AD组及VD组血清同型半胱氨酸水平明显高于健康对照组,差异均有统计学意义(P<0.05);VD组血清叶酸水平明显低于AD组和健康对照组,差异均有统计学意义(P<0.05),AD组与健康对照组叶酸水平比较,差异无统计学意义(P>0.05)。结论检测AD和VD患者血清中炎症因子和各种生化指标,可为临床诊断提供有效的科学依据。
Objective To investigate the clinical significance of serum inflammatory factors and biochemical indicators in patients with Alzheimer′s disease and vascular dementia.Methods A total of 50 patients with Alzheimer′s disease(AD group)and 50 patients with vascular dementia(VD group)admitted to our hospital from July 2014 to July 2016 were selected.In addition,50 healthy people who came to our hospital for physical examination at the same time were selected as the control group,and various inflammatory factors in serum were compared,and various indicators in the three groups were analyzed.Results Triglyceride(TG),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC)of AD group and the VD group were significantly higher than that of control group(P<0.05),especially in the VD group.There were no significant differences of TG,LDL-C and TC between the AD group and the VD group(P>0.05),and no significant differences were found between the three groups in serum HDL-C levels(P>0.05).Tumor necrosis factor(TNF)-α,C-reactive protein(CRP)and IL-6 of AD group were significantly higher than that of the VD group and the control group(P<0.05).There was no significant difference in the levels of IL-6 and TNF-αbetween the VD group and the control group(P>0.05),but CRP level of the VD group was significantly higher than that in the control group(P<0.05).Serum homocysteine(Hcy)of AD group and VD group were significantly higher than that of control group(P<0.05).While folate level of VD group was significantly lower than that of AD group and control group(P<0.05),and there was no significant difference between AD group and control group in folate level(P>0.05).Conclusion The test of analyzing the inflammatory factors and various biochemical indicators in serum could provide an effective scientific basis for clinical practice.
作者
亢涛
KANG Tao(Department of Clinical Laboratory,Fuxing Hospital Affiliated to Capital Medical University,Beijing 100038,China)
出处
《检验医学与临床》
CAS
2019年第20期2966-2968,共3页
Laboratory Medicine and Clinic
关键词
阿尔茨海默病
血管性痴呆
炎症因子
生化指标
Alzheimer′s disease
vascular dementia
inflammatory factors
biochemical indicators
