摘要
目的银杏内酯对血管性痴呆患者认知功能及血清Hcy、hs-CRP、TNF-α水平的影响。方法选取血管性痴呆患者152例,随机分为单药治疗组和联合治疗组,各76例。单药治疗组采用长春西汀进行治疗,联合治疗组在单药治疗组的基础上采用银杏内酯进行治疗,两组均治疗4周。比较两组疗效、血清因子水平及认知功能、生活质量。结果治疗后,联合治疗组总有效高于单药治疗组(P<0.05);两组MMSE、MoCA、MBI评分均较治疗前升高,且联合治疗组高于单药治疗组(P<0.05);两组血清Hcy、hs-CRP、TNF-α水平及CDR评分均较治疗前降低,且联合治疗组低于单药治疗组(P<0.05)。结论银杏内酯联合长春西汀治疗血管性痴呆,可有效降低患者血清Hcy、hs-CRP、TNF-α水平,抑制疾病进展,改善患者认知功能和生活质量,具有良好的治疗效果。
Objective To observe the effects of ginkgolide on cognitive function and serum Hcy,HS-CRP and TNF-levels in patients with vascular dementia.Methods From August 2019 to November 2020,152 patients with vascular dementia admitted to the department of Neurology of our hospital were randomly divided into single drug treatment group(76 cases)and combined treatment group(76 cases).The monotherapy group was treated with vinpocetine,and the combination therapy group was treated with ginkgolide on the basis of the monotherapy group.Both groups were treated for 8 weeks.The efficacy,serum factor level and cognitive function of the two groups were compared.Results After treatment,the total effective rate of the combined treatment group was significantly higher than the single treatment group(P<0.05).Compared with before treatment,serum Hcy,hs-CRP,TNF-αlevels and CDR scores of the two groups decreased after treatment,and the combination treatment group was lower than the single drug treatment group and there were statistical significantly differences(P<0.05).Compared with before treatment,MMSE and MoCA,MBI in the two groups increased after treatment,and the combined treatment group was higher than the single drug treatment group and there were statistical significantly differences(P<0.05).Conclusion Ginkgolide combined with vinpocetine in the treatment of vascular dementia can effectively reduce the serum levels of Hcy,hs-CRP and TNF-α,inhibit the disease progression,improve the cognitive function and living quality of patients,and have a good therapeutic effect.
作者
包蕾
马莉
Bao Lei;Ma Li(Department of Neurology,Affiliated Central Hospital of Shenyang Medical College,Shenyang 110024,Liaoning,China)
出处
《贵州医药》
2021年第8期1191-1193,共3页
Guizhou Medical Journal
