摘要
目的:通过星点设计-效应面法对清宁胶囊填充工艺进行优化。方法:以药粉粒径、料斗加料量、相对湿度为考察因素,以清宁胶囊装量为考察评分指标,采用星点设计试验优选胶囊填充的工艺参数,应用多元线性模型和二次多项式模型描述考察指标和3个考察因素之间的数学关系,绘制效应面和等高线图,利用效应面法确定胶囊填充的最佳工艺参数并进行验证试验。结果:最优胶囊填充工艺条件为:药粉粒径为120目,料斗加料量在1/3~1/2之间,环境相对湿度控制为65%。结论:基于星点设计-效应面法确定的胶囊填充工艺稳定,可预测性优,为制剂的大批量生产奠定了基础。
Objective:To optimize the filling process parameters of Qingning Capsule by central composite design-response surface methodology.Methods:The powder particle size,hopper feeding amount and relative humidity were taken as the investigation factors.The Qingning capsule loading capacity was used as the evaluation index.The central composite design experiment was used to optimize the capsule filling process parameters.The multivariate linear model and the quadratic polynomial model were used to describe the method.The mathematical relationship between the indicator and the three factors was drawn,and the effect surface and contour map were drawn.The optimal process parameters of the capsule filling were determined by the response surface methodology and the verification test was carried out.Results:The optimal capsule filling process conditions were as follows:the particle size of the powder was 120 mesh,the feed amount of the hopper was between 1/3 and 1/2,and the relative humidity of the environment was controlled to be 65%.Conclusion:Based on the central composite design-response surface methodology,the capsule filling process is stable and predictable,which lays a foundation for the mass production of the preparation.
作者
李俊江
詹文强
李季文
Li Junjiang;Zhan Wenqiang;Li Jiwen(The research and preparation center of provincial hospital of Traditional Chinese Medicine,Lanzhou 730050,China;Central Laboratory of Gansu Province Academy of Chinese Medicine,Lanzhou 730050,China)
出处
《亚太传统医药》
2019年第9期34-37,共4页
Asia-Pacific Traditional Medicine
关键词
清宁胶囊
胶囊装量
填充工艺
星点设计
效应面法
Qingning Capsule
Capsule Loading
Filling Process
Central Composite Design
Response Surface Methodology
