摘要
目的评价厄贝沙坦联合氨氯地平治疗老年高血压患者效果。方法研究对象为方便选取2015年2月-2018年2月老年高血压患者例数200例,采用每日患者挂号的自然序列,单号为观察组,双号为对照组,分别实施厄贝沙坦联合氨氯地平治疗以及常规治疗,将两组患者的血压水平、治疗效果、肾小管功能指标以及尿微量蛋白指标进行对比。结果治疗后,观察组收缩压(125.52±1.34)mmHg、舒张压(70.64±1.32)mmHg均低于对照组(t=54.458 3、57.286 2,P<0.05);观察组NAG (11.32±1.02)mg/L、Kim^-1(469.32±1.54)ng/L,较对照组指标更有优势(t=34.328 8、288.895 5,P<0.05);观察组治疗总有效率95.00%高于对照组74.00%(χ2=16.835 3,P<0.05);治疗后,观察组老年高血压患者mAlb(14.09±5.61)mg/L、RBP(0.21±0.06)mg/L低于对照组(t=7.730 2,16.641 0,P<0.05)。结论厄贝沙坦联合氨氯地平治疗老年高血压患者的效果十分显著,且安全性较高,对肾脏具有保护作用。
Objective Convenient selected to evaluate the effect of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients. Methods A total of 200 elderly patients with hypertension from February 2015 to February 2018 were enrolled. The natural sequence of daily patient registration was used. The single number was the observation group and the double number was the control group. The irbesartan combined with amlodipine and conventional treatment were performed. Blood pressure levels, treatment effects, renal tubular function indicators, and urine microprotein indicators were compared between the two groups. Results After treatment the systolic blood pressure (125.52±1.34) mmHg and diastolic blood pressure (70.64±1.32) mmHg in the observation group were lower than those in the control group (t=54.458 3, 57.286 2,P<0.05);observation group NAG (11.32±1.02) mg/L, Kim-1 (469.32±1.54) ng/L, which was superior to the control group (t=34.328 8,288.895 5,P<0.05);the total effective rate of the observation group was 95.00% higher than that of the control group 74.00%(χ2=16.835 3,P<0.05);after treatment, mAlb (14.09±5.61) mg/L and RBP (0.21±0.06) mg/L in elderly hypertensive patients in the observation group were lower than the control group(t=7.730 2,16.604 1,P<0.05). Conclusion The efficacy of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients is very significant, and it is safe and has a protective effect on the kidney.
作者
聂祥碧
NIE Xiang-bi(Department of Cadre Medical Care Clinic,Guizhou Provincial People's Hospital,Guiyang,Guizhou Province,550001 China)
出处
《中外医疗》
2019年第25期97-99,共3页
China & Foreign Medical Treatment
关键词
厄贝沙坦
氨氯地平
老年高血压
效果评价
Irbesartan
Amlodipine
Elderly hypertension
Effect evaluation
