摘要
合成了7-(双十二烷基胺)-4-羟甲基香豆素,通过光敏性的酯键将其引入到纳米载体GNR@SiO2-DOX@CouC12-HA(GSDCH)中,实现了药物释放的智能控制,制备了具有良好生物相容性与对Hela细胞的靶向性的纳米载体.结果表明:单独的阿霉素与癌细胞共孵育后,Hela细胞的存活率在50%以上;将DOX先载入纳米载体后,细胞存活率低于20%.与仅使用DOX相比,GSDCH结合了热疗和化疗,对Hela肿瘤细胞的治疗效果显著提高,在肿瘤治疗中具有很大的潜力.
7-(double dodecylamine)-4-hydroxymethylcoumarin was synthesized and introduced into the nano-carrier GNR@SiO2-DOX@CouC12-HA(GSDCH)through photosensitive ester bonds,thus realizing intelligent control of drug release.The prepared nanocarrier had good biocompatibility and targetability to Hela cell.The results indicated that after DOX alone was incubated with cancer cells,the Hela cell viability was higher than 50%,while the cell survival rate was lower than 20%when loading DOX into the nanocarrier first.Compared with treating only with DOX,the GSDCH provided a combination of photothermal and chemotherapy,significantly enhanced therapeutic efficiency to Hela tumor cells and demonstrated great potential in the treatment of tumors.
作者
孙宏浩
马正虎
秦汤
赵晓双
SUN Honghao;MA Zhenghu;QIN Tang;ZHAO Xiaoshuang(“111” Subject Innovation and Intelligence Base for Cellular Regulation and Molecular Medicine,Key Laboratory of Industrial Microbiology in Hubei,Key Laboratory of Fermentation Engineering of Ministry of Education,School of Bioengineering and Food,Hubei University of Technology,Wuhan 430068,China)
出处
《中南民族大学学报（自然科学版）》
CAS
2019年第3期331-336,共6页
Journal of South-Central University for Nationalities：Natural Science Edition
基金
国家自然科学基金资助项目(21501054)
湖北省自然科学基金资助项目(2014CFA080)
湖北省科技厅高等学校优秀中青年科技创新团队计划(T201705)
湖北省大学生创新训练资助项目(201810500108)
关键词
纳米载体
控制释放
金纳米棒
化学治疗
光热治疗
nanocarrier
controlled release
gold nanorods
chemotherapy
potothermal therapy
