摘要
由于在改善药物溶解度、体内靶向递送等方面的优势,纳米药物成为药学领域研究的热点。随着纳米技术在医药领域研究的不断深入,也伴随着分析技术方法的进步与完善。该文概述了纳米药物粒度、形貌、包封率及载药量等经典分析技术方法的新进展和近年来应用的新分析技术方法,为纳米药物及载体的深入分析与研发提供了技术方法和研究思路。
Objective Due to its advantages in improving drug solubility,in vivo targeted delivery,nanomedicine has become a hotspot in the field of pharmacy.With the continuous research of nanotechnology in the field of medicine,it is also accompanied by the progress and improvement of analytical methods.This paper is summarized the new developments in classical analytical methods such as particle size,morphology,encapsulation efficiency,and drug loading of nanomedicines,and new analytical techniques and methods that have appeared in recent years,providing technical methods and research ideas for the in-depth analysis and development of nanomedicines and carriers.
作者
靳雅丽
杨德智
杨世颖
张丽
吕扬
JIN Yali;YANG Dezhi;YANG Shiying;ZHANG Li;LYU Yang(Research Centre of Polymorphic Drugs, Beijing Key Laboratory of Polymorphic Drug, Peking Union Medical College, Institute of Materia Medica &Chinese Academy of Medical Sciences, Beijing 100050, China)
出处
《医药导报》
CAS
北大核心
2021年第4期491-495,共5页
Herald of Medicine
基金
国家重点研发计划(2016YFC1000900)
国家科技重大专项-重大新药创制(2017ZX09101001003,2018ZX09711001-010)
中国医学科学院医学与健康科技创新工程(2017-I2M-1-010)
国家自然科学基金(81703473)
十三五天然产物-丹酚酸A(2018ZX09711001-003-022)。
关键词
纳米技术
纳米药物
分析方法
Nanotechnology
Nanomedicine
Analytical methods
