摘要
目的通过对痛风性关节炎急性发作期的临床疗效进行统计学分析,以评价通调营卫法治疗痛风性关节炎急性发作期的临床疗效。方法将90例符合标准的痛风性关节炎急性发作期患者随机分为治疗组和对照组各45例(实际完成观察治疗组44例,对照组43例),对照组给予美洛昔康片7.5mg,每日1次,口服治疗,治疗组使用李莉主任医师经验方痛风1号方水煎口服治疗,疗程均为2周。观察治疗前及治疗后1周、2周的临床疗效及临床症状积分、疼痛视觉模拟评分(VAS),并检测治疗前后血沉(ESR)、超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、环氧合酶2(COX-2)水平,同时观察不良反应。结果治疗组总有效率97.73%高于对照组的83.72%(P<0.05)。两组治疗前症状积分、VAS评分、各实验室指标比较,差异均无统计学意义(均P>0.05)。治疗后1周、2周,两组症状积分、VAS评分、各实验室指标均较治疗前改善,且治疗组改善程度优于对照组(P<0.05),以治疗1周时效果最佳(P<0.01)。两组治疗中未发现安全检测指标不正常及出现药物过敏者;治疗组3例大便偏稀,对照组6例胃脘痛及反酸、嘈杂,5例纳差,均经简单对症处理后缓解,未出现因不良反应而退出试验情况。治疗组不良反应发生情况低于对照组(P<0.05),治疗组安全性较高。结论采用通调营卫法,李莉主任医师经验方痛风1号方水煎口服治疗痛风性关节炎急性发作期,具有较好的临床疗效,提高日常生活能力,降低炎症因子,能更好地改善病情,不良反应少,安全性高。
Objective:To evaluate the clinical efficacy of Harmonizing Ying and Wei method on acute attack of gouty arthritis with statistical analysis.Methods:90 patients were randomly divided into the treatment group and the control group,45 in each(44 in the treatment group and 43 in the control group were actually observed).The control group was treated with meloxicam tablets,7.5 mg QD orally.On the basis,the treatment group was treated with Gout Formula No.1 prescription of Director Li Li.The course of treatment was 2 weeks.The comprehensive clinical efficacy and clinical symptoms score and pain severity score(VAS)were observed before and after treatment for 1 and 2 weeks.The levels of ESR,H-CRP,IL-1β,TNF-α and COX-2 were measured before and after treatment.The adverse reactions were also observed.Results:The total effective rate of the treatment group was 97.73%,higher than 83.72% of the control group(P < 0.05).There was no significant difference in symptom score, VAS score and laboratory indexes between the two groups before treatment(all P > 0.05).One and two weeks after treatment,those of the two groups were improved compared with before treatment,and the improvement of the treatment group was better than that of the control group(P < 0.05),especially one week after treatment(P < 0.01). No abnormal safety test indexes and drug allergies were found in the two groups.Three cases in the treatment group had sparse stool;six cases in the control group had epigastric pain,acid reflux and noise,and five cases had poor appetite.All of them were relieved after simple symptomatic treatment.There was no withdrawal from the trial due to adverse reactions.The incidence of adverse reactions in the treatment group was lower than that in the control group(P < 0.05),and the safety of the treatment group was higher.Conclusion:With the method of Harmonizing Ying and Wei,Director Li Li's experience prescription gout 1 decoction oral treatment has better clinical efficacy on acute gouty arthritis attack period,and can improve daily li
作者
马秀琴
牟善茂
焦静
高磊
隋晓琳
丁玉洁
李莉
Ma Xiuqin;Mou Shanmao;Jiao Jing(Rizhao Traditional Chinese Medicine Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Shandong,Rizhao 276800,China)
出处
《中国中医急症》
2019年第9期1536-1539,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
山东省名中医药专家传承工作室建设项目
李莉全省名中医药专家传承工作室
关键词
痛风性关节炎急性发作期
通调营卫
临床研究
Acute stage of gout arthritis
Harmonizing Ying and Wei
Clinical research
