摘要
目的:探讨茶碱类药物对慢性阻塞性肺疾病急性加重的治疗效果及不良反应。方法:选取2016年3月~2017年5月就诊于某院呼吸科诊断为AECOPD的患者150例,将患者随机分为多对照组、氨茶碱组和多索茶碱组各50例,所有患者依据病情予以对症支持治疗。在对症治疗的基础上,氨茶碱组予以氨茶碱治疗,多索茶碱组予以多索茶碱治疗,分析比较3组患者临床疗效、PaO2和PaCO2、肺通气功能及治疗期间不良反应的发生情况。结果:治疗3d及治疗7d后,经茶碱类药物治疗患者的显效率与治疗总有效率较对照组均有明显增加(P<0.05);氨茶碱和多索茶碱组患者血气分析中PaO2较对照组均明显升高(P<0.05),而PaCO2 较对照组明显下降(P<0.05);氨茶碱和多索茶碱组FEV1/FVC、FEV1/预计值和PEF/预计值较对照组均有明显增加(P<0.05),而多索茶碱组以上各指标较氨茶碱组均有明显升高(P<0.05);治疗期间氨茶碱组不良反应发生率较对照组均明显增加(P<0.05)。结论:多索茶碱因其治疗作用显著而不良反应少,值得AECOPD的临床推广应用,而氨茶碱因其不良反应需谨慎应用,应用时需对其不良反应进行密切监测。
Objective: To investigate the therapeutic effect and adverse reactions of theophylline on acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: 150 patients with AECOPD diagnosed in respiratory department of a hospital from March 2016 to May 2017 were selected and randomly divided into multi-control group, aminophylline group and doxofylline group with 50 cases in each group. All patients were given symptomatic supportive treatment according to their condition. On the basis of symptomatic treatment, aminophylline group was treated with aminophylline, and doxofylline group was treated with doxofylline. The clinical efficacy, PaO 2 and PaCO 2, pulmonary ventilation function and adverse reactions during treatment were analyzed and compared among the three groups. Results: After 3 days of treatment and 7 days of treatment, the marked and total effective rate of theophylline-treated patients was significantly higher than those of control group ( P <0.05);PaO 2 in blood gas analysis of aminophylline and doxofylline group was significantly higher than that of control group ( P <0.05), while PaCO 2 was significantly decreased compared with the control group ( P <0.05);FEV1/FVC, FEV1/predicted value and PEF/predicted value of aminophylline and doxofylline group were significantly increased compared with those of control group ( P <0.05). All the above indexes in the doxophylline group were significantly higher than those in the aminophylline group ( P <0.05). The incidence of adverse reactions in aminophylline group during the treatment was significantly higher than that in control group ( P <0.05). Conclusion: Doxofylline is worthy of clinical application on AECOPD because of its remarkable therapeutic effect and few adverse reactions. Aminophylline should be applied cautiously because of its adverse reactions, and its adverse reactions should be closely monitored when applied.
作者
叶连萌
陈若丹
黄晓颖
Ye Lianmeng(Department of Respiratory Medicine,Wenzhou Medical University Theorem Clinical College,Wenzhou 325000)
出处
《数理医药学杂志》
2019年第9期1349-1351,共3页
Journal of Mathematical Medicine
