摘要
目的分析胃癌筛查与诊断中血清细胞质胸苷激酶(thymidine kinase 1,TK1)、胃蛋白酶原(PG)、糖类抗原-4(CA72-4)检测的应用价值。方法选取2017年2月—2018年1月来该院诊治的86例胃部疾病患者为研究对象,浅表性胃炎、萎缩性胃炎、胃溃疡、胃癌患者分别有25例、22例、18例、21例,选取同时期50名健康体检者为对照组,所有研究对象均采用增强化学发光法检测TK1、PG、CA72-4。对各组测定结果行对比分析。结果胃癌组患者TK1、PGⅡ、CA72-4水平分别为(112.68±20.65)pmol/L、(15.98±5.89)μg/L、(12.75±3.68)U/mL,均高于浅表性胃炎、萎缩性胃炎、胃溃疡组,PGⅠ水平为(62.35±14.85)μg/L,低于浅表性胃炎、萎缩性胃炎、胃溃疡组,差异有统计学意义(P<0.05)。结论胃癌筛查与诊断中TK1、PG、CA72-4具有良好的应用价值。
Objective To analyze the application value of serum cytoplasmic thymidine kinase (TK1), pepsinogen (PG) and carbohydrate antigen-4 (CA72-4) in gastric cancer screening and diagnosis. Methods 86 patients with gastric diseases who were treated in our hospital from February 2017 to January 2018 were selected as subjects. There were 25 cases, 22 cases and 18 cases, 21 cases of superficial gastritis, atrophic gastritis, gastric ulcer and gastric cancer. 50 healthy subjects in the same period were selected as the control group. All subjects were tested for TK1, PG and CA72-4 by enhanced chemiluminescence method. The results of each group were compared and analyzed. Results The levels of TK1, PGII and CA72-4 in the gastric cancer group were (112.68±20.65) pmol/L,(15.98±5.89)μg/L,(12.75±3.68) U/mL, respectively, which were higher than superficial gastritis and atrophy. In the gastritis and gastric ulcer group, the PGI level was (62.35±14.85)μg/L, which was lower than that of superficial gastritis, atrophic gastritis and gastric ulcer group (P<0.05). Conclusion TK1, PG and CA72-4 have good application value in the screening and diagnosis of gastric cancer.
作者
季秀成
李亮
JI Xiu-cheng;LI Liang(Department of Clinical Laboratory,Chuzhou Hospital of TCM,Huai'an,Jiangsu Province,223200 China)
出处
《世界复合医学》
2019年第8期123-124,127,共3页
World Journal of Complex Medicine
