摘要
目的观察分析血清细胞质胸苷激酶(TK1)、胃蛋白酶原(PG)和糖类抗原(CA72-4)检测在胃癌筛查以及诊断中的应用价值。方法选择我院2015年1月至2016年6月收治的300例受检者,其中包括胃癌患者63例、萎缩性胃炎患者57例、胃溃疡患者55例、浅表性胃炎患者65例以及健康体检者60例,检测患者的血清TK1、PGⅠ、PGⅡ以及CA72-4水平。结果五组血清TK1、PGⅠ、PGⅡ及CA72-4水平之间比较,差异有统计学意义(P<0.05)。胃癌组血清TK1、PGⅡ和CA72-4水平明显的升高,PGⅠ水平明显的降低,与其它各组比较,差异均具有统计学意义(P<0.05)。联合检测TK1、PGⅠ、PGⅡ及CA72-4四项的敏感性显著升高,但特异性有所下降,与单项检测比较,差异均有统计学意义(P<0.05)。结论血清TK1、PGⅠ、PGⅡ以及CA72-4四项联合检测可以有效提高胃癌的检出率,在早期诊断胃癌方面具有十分重要的临床应用价值。
Objective To explore the evaluation of serum TK1,PG and CA72-4detection in gastric cancer screening and diagnosis.Methods The serum TK1,PG I,PGII and CA72-4were detected in 300 subjects from January 2015 to June 2016 in our hospital,including 63 patients with gastric cancer,57 patients with atrophic gastritis,55 patients with gastric ulcer,65 patients with superficial gastritis and 60 healthy controls.Results The level of serum TK1,PG I,PG II and CA72-4among the five groups had significant differences（P〈0.05）.Compared with other groups,the level of serum TK1,PG II and CA72-4in Gastric cancer group were significantly increased,the level of PG I decreased,there were significant differences（P〈0.05）.The sensitivity of combined detection of TK1,PG 1,PG 2and CA72-4significantly increased,but the specificity decreased slightly,compared with single detection,the differences were statistically significant（P〈0.05）.Conclusion The combined detection of serum TK1,PG 1,PG 2and CA72-4can effectively improve the positive detection rate of gastric cancer.It has important application value in the early diagnosis of gastric cancer.
出处
《中国实验诊断学》
2017年第10期1682-1684,共3页
Chinese Journal of Laboratory Diagnosis
