摘要
目的探讨细胞质胸苷激酶I（TKI）检测对肺癌诊断的I临床价值。方法利用增强化学发光法（ECLA）检测65例肺癌患者血清TKl的含量，同时检测20例肺部良性疾病和20名健康志愿者血清中的TKl含量。结果肺癌患者TKI水平（3．71±2．86pmol／L）显著高于肺部良性疾病组（1．70±1．61pmol／L）和正常对照组（1．18±1．13pmol／L）（P〈0．01）；但肺部良性疾病组和正常对照组之间差异无统计学意义（JP〉0．05）。TKl的ROC曲线下面积为0.81，诊断肺癌的准确度中等偏高。结论TKl是一个有价值的肿瘤标志物，它的检测有助于肺癌的诊断。
Objective To investigate the diagnostic value of serum thymidine kinase I（TK1） in lung carcinoma. Methods The levels of TKI in 65 patients with lung cancer,20 with benign lung disease and 20 normal controls were determined by enhanced chemiluminescence assay. Results The levels of TK1 in participants with lung carcinoma（3.71 ＋ 2.86pmol/L） were much higher than those in participants with benign disease（1.70 ＋ 1.61pmol/L） and normal controls（1.18 ＋ 1.13pmol/L）（P 〈 0.01）,but there was no significant difference between patients with benign disease and normal controls（P 〉 0.05）.The area under curve（AUC） of TIll was 0.81 by ROC analysis,and the diagnostic accuracy to lung carcinoma was moderate to high.Conclusion The detection of TK1 may have value in the diagnosis of lung carcinoma.
出处
《中国血液流变学杂志》
CAS
2011年第4期658-660,共3页
Chinese Journal of Hemorheology
关键词
胸苷激酶
增强化学发光法
肺癌
Thymidine kinase
Enhanced chemiluminescence assay
Lung carcinoma
