摘要
目前恶性肿瘤在人群的发病率逐渐上升,严重威胁着人类的健康。许多恶性肿瘤患者早期无特异性的临床表现,检查确诊时肿瘤已处于中晚期,治疗效果及预后较差,因此对于恶性肿瘤的早期诊断刻不容缓。随着目前对于血清中肿瘤标志物的研究的深入开展,一种新的细胞增殖标志物,即胸苷激酶1(thymidine kinase 1, TK1),已被证实在肿瘤的早期诊断、治疗效果评估及预后的判断等方面具有重要作用。本文就胸苷激酶1的结构、功能、作用机制以及在恶性肿瘤中的研究进展等进行综述。
At present,the incidence of malignant tumors in the population is gradually rising,which is a serious threat to human health.Many patients with malignant tumors have no specific clinical manifestations in the early stage.The tumors are in the advanced stage when the diagnosis is confirmed,and the therapeutic effect and prognosis are poor.For malignant tumors,early diagnosis is an urgent task.At present,the research on serum tumor markers has been carried out in depth.A new cell proliferation marker,thymidine kinase 1(TK1),has been confirmed to be important in the early diagnosis of tumors,evaluation of therapeutic effects and judgment of prognosis effect.This article reviews the structure,function,mechanism of action of thymidine kinase 1 and its research progress in malignant tumors.
作者
周家田
梁卫东
吴鹏
颜神超
ZHOU Jiatian;LIANG Weidong;WU Peng;YAN Shenchao(Department of Thoracic and Cardiovascular Surgery,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《生命的化学》
CAS
CSCD
2019年第3期498-503,共6页
Chemistry of Life
关键词
胸苷激酶1
DNA合成
细胞增殖
恶性肿瘤
thymidine kinase 1
DNA synthesis
cell proliferation
malignant tumor
