摘要
目的探讨脂肪因子nesfatin-1与妊娠期糖尿病(Gestational diabetes mellitus,GDM)患者脂肪细胞型脂肪酸结合蛋白(Adipocyte Fatty Acid BindingProtein,AFABP)、瘦素、胰高血糖素样肽-1(Glucagon-like peptide 1,GLP-1)的相关性。方法选取2015年3月~2017年6月我院妇产科收治的68例妊娠期糖尿病患者作为GDM组,选取同期50例正常糖耐量(Normal Glucose Tolerance,NGT)妊娠妇女作为NGT组。对两组患者行回顾性分析,采用SPSS对脂肪因子nesfatin-1和糖尿病患者相关指标进行pearson相关性及多元回归分析。结果GDM组产前体重指数(BMI)、△BMI(产前BMI-孕前BMI)、空腹血糖、空腹胰岛素、nesfatin-1、瘦素、AFABP均显著高于NGT组,差异有统计学意义(P<0.05);两组产妇孕前BMI及GLP-1差异无统计学意义(P>0.05);pearson相关性分析提示nesfatin-1与孕前BMI、产前BMI、孕期增加体重、△BMI、空腹胰岛素、AFABP相关(P<0.05);多元回归分析提示,产前BMI及空腹胰岛素是nesfatin-1的独立危险因素。校正空腹胰岛素和产前BMI后logistic回归分析nesfatin-1、瘦素、AFABP为GDM的独立危险因素(P<0.05)。结论GDM患者nesfatin-1与AFABP呈正相关,nesfatin-1、AFABP、瘦素为GDM患者的独立危险因素,血清GLP-1与GDM无关。
Objective To investigate correlation between adiponectin nesfatin-1 and adipocyte fatty acid binding protein (AFABP),leptin,and glucagon-like peptide-1 (GLP-1) in patients with gestational diabetes mellitus (GDM).Methods 68 cases of GDM (GDM group) and 50 cases of normal glucose tolerance (NGT group) pregnant women admitted to the Department of Obstetrics and Gynecology in our hospital from March 2015 to June 2017 were selected.Then their clinical data were retrospectively analyzed.Pearson correlation and multivariate regression analysis of adipokine nesfatin-1 and related indicators of diabetes mellitus were performed by SPSS.Results The prenatal BMI,fasting blood glucose,fasting insulin,nesfatin-1,leptin and AFABP in GDM group were significantly higher than those in NGT group ( P <0.05).Pearson correlation analysis showed that nesfatin-1 was correlated with prenatal BMI,prenatal BMI,weight gain during pregnancy,BMI,fasting insulin and AFABP (R values were 0.491,0.638,0.341,0.492,0.435,0.582,P <0.05).Multivariate regression analysis showed that prenatal BMI and fasting insulin were independent risk factors for nesfatin-1.Nesfatin-1,leptin and AFABP were independent risk factors for GDM by adjusted fasting insulin and logistic regression analysis after prenatal BMI ( P <0.05).Conclusion The nesfatin-1 was positively correlated with AFABP in GDM patients.Nesfatin-1,AFABP,leptin are independent risk factors in patients with GDM.Moreover,the study also indicates that the Serum GLP-1 has no correlation with GDM.
作者
齐茹
李涛淘
张薇
伦颖洁
刘妍
QI Ru;LI Taotao;ZHANG Wei;LUN YINGjie;LIU Yan(Obstetrics and Gynecology Department,Panjin Liao Qil Gem Flower Hospital,Panjin 124010,Liaoning,China)
出处
《西部医学》
2019年第9期1432-1435,共4页
Medical Journal of West China
基金
辽宁省教育厅科研基金(L2010687)
