摘要
目的探讨初诊2型糖尿病(T2DM)患者血清糖类抗原19-9(CA19-9)与胰岛β细胞功能的相关性。方法选择初诊T2DM患者59例,健康对照者(NC)59例,均行口服75 g葡萄糖耐量试验(OGTT)及胰岛素释放试验,分别用稳态模型HOMA-β和HOMA-IR评估胰岛β细胞功能和胰岛素抵抗程度,检测血清CA19-9及其他生化指标。结果 T2DM患者血清CA19-9水平[中位数(第25、75百分位数)]为14.48(12.05,19.30)U/mL,高于NC组[5.03(4.37,7.38)U/mL],P<0.05。糖化血红蛋白A1c(HbA1c)>7.0%T2DM患者组、HbA1c<7.0%T2DM患者组及NC组血清CA19-9水平依次下降(P<0.05)。血清CA19-9水平与总胆固醇(TC)、空腹血糖(FPG)、OGTT 2 h血糖(2hPG)、HbA1c呈正相关(r分别为0.320、0.786、0.756、0.782,P均<0.01),与空腹胰岛素(FINS)、HOMA-β呈负相关(r分别为-0.438、-0.644,P<0.05或0.01)。以血清CA19-9为因变量,行多元逐步回归分析,有FPG、HbA1c、HOMA-β进入最后方程(P<0.01)。结论初诊T2DM患者血清CA19-9水平高于NC组,与FPG、HbA1c和HOMA-β相关,可作为判断T2DM患者胰岛β细胞功能障碍的一种生物学标志物。
Objective：To explore the possible relationship between serum tumor marker carbohydrate antigen 19-9 （CA19-9） and pancreatic beta cell function in subjects with newly diagnosed type 2 diabetes mellitus （T2DM）. Methods：A total of 118 subjects was included and evenly divided into two groups, 59 patients with newly diagnosed T2DM and 59 normal control. Two tests, 75 grams oral glucose tolerance test and insulin release test, were performed. Insulin secretion and insulin resistance were estimated by homeostasis model assessment （HOMA） beta cell function index and HOMA IR index respectively. The levels of serum CA19-9 were simultaneously determined by chemiluminescence method and other biochemical parameters were also measured. Results：Serum CA19-9 levels in T2DM group[14.48（12.05 19.30）U/mL] were significantly higher than those in normal control group[5.03（4.37 7.38）U/mL] （P〈0.05）. The level of serum CA19-9 in glycosylated hemoglobin （HbA1c） more than 7.0% group was significantly higher than that in HbA1c less than 7.0% group and normal control group （P〈0.05 or P〈0.01）. CA19-9 levels were positively correlated with total cholesterol, fasting plasma glucose （FPG）, 2 hour post oral glucose tolerance test （OGTT） plasma glucose （2hPG）, HbA1c, and negatively correlated with fasting insulin （FINS）, HOMA-beta cell function index （P〈0.05 or P〈0.01）. In multiple stepwise regression, FPG, HbA1c and HOMA beta index were significantly independent determinants for CA19-9 （P〈0.01）. Conclusion：Serum CA19-9 levels increased in patients with newly diagnosed T2DM and correlated with FPG、HbA1c and HOMA-β index. CA19-9 could be served as a biological marker of pancreatic beta cell dysfunction for newly diagnosed T2DM patients.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2013年第12期904-907,共4页
Chinese Journal of Clinical Laboratory Science
基金
江苏省自然科学基金(BK2009208)
江苏省卫生厅国际交流支撑计划及面上科技项目(H201247)
镇江市社会发展基金(SH2012027)
镇江市医学重点人才项目(2010)
关键词
糖类抗原19-9
初诊
2型糖尿病
胰岛Β细胞功能
carbohydrate antigen 19-9
newly diagnosed type 2 diabetes mellitus
pancreatic beta cell function
