摘要
目的探讨老年类风湿关节炎患者接受来氟米特、羟氯喹联合治疗的临床疗效及对机体血脂水平的影响效果.方法采用随机数字表法将解放军970医院2016年11月至2018年10月80例老年类风湿关节炎患者分为两组,每组40例.研究组在常规治疗基础上加用来氟米特、羟氯喹,对照组在常规治疗基础上加用羟氯喹.比较两组治疗效果和血脂水平.结果研究组临床总有效率(82.22%)高于对照组(64.44%),差异有统计学意义(P<0.05).两组用药前三酰甘油(TG)、血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异未见统计学意义(P>0.05);治疗后研究组TG、TC、LDL-C水平下降幅度及HDL-C水平上升幅度均优于对照组,差异有统计学意义(P<0.05).结论应用来氟米特、羟氯喹联合治疗老年类风湿关节炎效果显著,有利于提高其机体血脂水平改善效果.
Objective To investigate the clinical effect of leflunomide and hydroxychloroquine in elderly patients with rheumatoid arthritis.Methods Eighty elderly patients with rheumatoid arthritis from November 2016 to October 2018 in the 970th Hospital of Chinese PLA were divided into two groups by random number table method,with 40 cases in each group.The study group was treated with flunomide and hydroxychloroquine on the basis of routine treatment,while the control group was treated with hydroxychloroquine on the basis of routine treatment.The therapeutic effect and blood lipid level were compared between the two groups.Results The total clinical effective rate of the study group(82.22%)was higher than that of the control group(64.44%)with statistical significance(P<0.05);there was no significant difference in the levels of triglyceride(TG),total serum cholesterol(TC),high-density lipoprotein cholesterol(LDL-C),low-density lipoprotein cholesterol(LDL-C)between the two groups before medication(P>0.05).After treatment,the decrease of TG,TC,HDL-C levels and the increase of HDL-C levels in the study group were better than those in the control group,with statistical significance(P<0.05).Conclusions The effect of leflunomide and hydroxychloroquine in the treatment of elderly rheumatoid arthritis is remarkable,which is conducive to improving the body’s blood lipid level.
作者
刘晓光
白艳春
Liu Xiaoguang;Bai Yanchun(Department of Rheumatology,the 970th Hospital of Chinese PLA,Weihai 264200,China)
出处
《中国实用医刊》
2019年第14期106-108,共3页
Chinese Journal of Practical Medicine
关键词
类风湿关节炎
羟氯喹
来氟米特
联合治疗
治疗效果
血脂水平
Rheumatoid arthritis
Hydroxychloroquine
Leflunomide
Combination therapy
Therapeutic effect
Blood lipid level
