摘要
目的探讨小剂量泼尼松联合来氟米特、硫酸羟氯喹治疗类风湿性关节炎的临床疗效。方法将96例类风湿性关节炎患者按治疗方法的不同分为观察组和对照组,每组48例。2组均采用来氟米特片联合硫酸羟氯喹片治疗。在此基础上,对照组采用洛索洛芬钠分散片治疗,观察组采用醋酸泼尼松片治疗。观察2组治疗前、治疗3个月后视觉模拟评分法(VAS)评分、疾病活动性评分系统(DAS)28评分和免疫指标[血清红细胞沉降率(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)]、骨密度T值的变化及不良反应发生率。结果 2组治疗3个月后血清RF水平比较差异无统计学意义(P>0.05)。与对照组比较,观察组治疗3个月后VAS、DAS28评分和血清ESR、CRP水平及骨密度T值均降低更明显(均P<0.05)。2组在治疗期间均未见明显的不良反应。结论小剂量泼尼松联合来氟米特、硫酸羟氯喹治疗类风湿性关节炎可减轻患者的疼痛,降低炎性指标水平,且不会增加骨质疏松的风险。
Objective To explore the clinical effect of low-dose prednisone combined with leflunomide and hydroxychloroquine sulfate on rheumatoid arthritis.Methods Ninety-six patients with rheumatoid arthritis were treated with leflunomide tablets and hydroxychloroquine sulfate tablets.In addition,patients were assigned to receive either loxoprofen sodium dispersible tablets(control group,n=48)or prednisone acetate tablets(observation group,n=48).Visual analogue scale(VAS)score,28-joint disease activity score(DAS28),serum erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF),bone density T value and incidence of adverse reactions were observed before and treatment for 3 months.Results There was no significant difference in serum RF level between the two groups after 3 months of treatment(P>0.05).Compared with control group,the VAS,DAS28 score,serumESR,CRP level and bone density T value significantly decreased in observation group after 3 months of treatment(P<0.05).No obvious adverse reactions were found in both groups.Conclusion Low-dose prednisone combined with leflunomide and hydroxychloroquine sulfate can reduce the pain and inflammatory indicators and does not increase the risk of osteoporosis in the treatment of rheumatoid arthritis.
出处
《实用临床医学（江西）》
CAS
2017年第10期10-12,共3页
Practical Clinical Medicine
关键词
类风湿性关节炎
泼尼松
来氟米特
硫酸羟氯喹
疗效
rheumatoid arthritis
prednisone
leflunomide
hydroxychloroquine sulfate
curative effect
