摘要
目的探讨复方甘草酸苷片联合枸地氯雷他定片治疗慢性特发性荨麻疹的临床疗效。方法 120例慢性特发性荨麻疹患者,随机分为对照组和治疗组,每组60例。对照组患者采取枸地氯雷他定片治疗,治疗组患者采取复方甘草酸苷片联合枸地氯雷他定片治疗。观察比较两组患者的临床疗效及治疗前后风团数量、瘙痒积分、白细胞介素-6(IL-6)、免疫球蛋白E(IgE)水平。结果治疗组患者的治疗总有效率为100.00%,明显高于对照组的66.67%,差异有统计学意义(χ^2=24.000, P=0.000<0.05)。治疗前,两组患者风团数量、瘙痒积分、IL-6及IgE水平比较差异均无统计学意义(P>0.05)。治疗后,两组患者的风团数量少于治疗前,瘙痒积分、IL-6及IgE水平均明显低于治疗前,且治疗组患者风团数量少于对照组,瘙痒积分、IL-6及IgE水平均明显低于对照组,差异均有统计学意义(P<0.05)。结论采用复方甘草酸苷片联合枸地氯雷他定片治疗慢性特发性荨麻疹的临床疗效显著,能够显著改善临床症状,降低IL-6、IgE水平,值得临床推广。
Objective To discuss the clinical efficacy of compound glycyrrhizin tablets combined with desloratadine citrate disodium tablets in the treatment of chronic idiopathic urticaria. Methods A total of 120 chronic idiopathic urticaria patients were randomly divided into control group and treatment group, with 60 cases in each group. The control group was treated with desloratadine citrate disodium tablets, and the treatment group was treated with compound glycyrrhizin tablets combined with desloratadine citrate disodium tablets. Observation and comparison were made on clinical efficacy, number of wind masses, itch score, interleukin-6(IL-6) and immunoglobulin E(IgE) levels before and after treatment between the two groups. Results The treatment group had obviously higher total treatment effective rate as 100.00% than 66.67% in the control group, and the difference was statistically significant(χ^2=24.000, P=0.000<0.05). Before treatment, there was no statistically significant difference in number of wind masses, itch score, IL-6 and IgE between the two groups(P>0.05). After treatment, both groups had less number of wind masses than those before treatment, and obviously lower itch score, IL-6 and IgE than those before treatment. The treatment group had less number of wind masses than that of the control group, and obviously lower itch score, IL-6 and IgE than that of the control group. Their difference was statistically significant(P<0.05). Conclusion Compound glycyrrhizin tablets combined with desloratadine citrate disodium tablets shows remarkable clinical efficacy in the treatment of chronic idiopathic urticaria, and it can significantly improve the clinical symptom and lower IL-6 and IgE level. It is worthy of clinical promotion.
作者
朴莉玲
张春韶
唐妮
张弘
PIAO Li-ling;ZHANG Chun-shao;TANG Ni(Shenzhen Longgang Central Hospital,Shenzhen 100191,China)
出处
《中国实用医药》
2019年第24期77-79,共3页
China Practical Medicine
关键词
复方甘草酸苷片
枸地氯雷他定片
慢性特发性荨麻疹
临床疗效
Compound glycyrrhizin tablets
Desloratadine citrate disodium tablets
Chronic idiopathic urticaria
Clinical efficacy
