摘要
目的:观察依巴斯汀、脾氨肽联合自血穴位注射治疗ASST(+)慢性荨麻疹的疗效及对免疫炎性因子的影响。方法:将156例ASST(+)慢性荨麻疹患者随机分为两组,对照组78例给予依巴斯汀、脾氨肽口服治疗,治疗组78例加用自血穴位注射疗法治疗,4周为1个疗程。连续治疗2个疗程后,观察两组患者临床疗效及对白细胞介素-4(IL-4)、白三烯(LT)、干扰素-γ(IFN-γ)的影响,并统计不良反应发生率。结果:治疗组慢性荨麻疹总有效率为91.03%,对照组慢性荨麻疹总有效率为78.21%,两组荨麻疹总有效率比较差异有统计学意义(P<0.05),治疗组慢性荨麻疹疗效优于对照组。两组治疗后LT、IL-4水平均显著降低,且治疗组水平显著低于对照组,比较差异均有统计学意义(P均<0.05);两组治疗后IFN-γ水平明显升高,且观察组优于对照组,比较差异均有统计学意义(P均<0.05);治疗组慢性荨麻疹不良反应发生率为5.13%,对照组慢性荨麻疹不良反应发生率为17.95%,两组不良反应发生率比较差异有统计学意义(P<0.05)。结论:依巴斯汀、脾氨肽联合自血穴位注射治疗ASST(+)慢性荨麻疹疗效显著。
Objective:To observe the therapeutic effect of ebastine and splenomegaly combined with auto-acupoint injection on chronic urticaria with ASST (+) and the effect on immunoinflammatory cytokines. Methods:156 patients with ASST (+) chronic urticaria were randomly divided into two groups. the control group were treated with ebastine and splenic aminopeptidase. the treatment group were treated with autologous blood point injection therapy on the basis of the control group. After two courses of continuous treatment,the clinical efficacy and the effects on the levels of interleukin-4,leukotrienes and interferon-γ in both groups were observed. Results:The total effective rate of chronic urticaria in treatment group was 91.03%,the total effective rate of chronic urticaria in control group was 78.21%,the total effective rate of urticaria in two groups was statistically significant difference ( P <0.05). The curative effect of chronic urticaria in treatment group better than the control group. The levels of LT and IL-4 in the two groups were significantly decreased after treatment,and the levels in the treatment group were significantly lower than those in the control group (all P <0.05). The incidence of adverse reactions of chronic urticaria was 5.13% in the treatment group and 17.95% in the control group,The incidence of adverse reactions in the control group was significantly higher than that of the control group.The incidence of adverse reactions was significantly different . Conclusion:The treatment of ASST (+) chronic urticaria withebastine and splenomegaly combined with autogenous blood injection has significant curative effect.
作者
林永丽
孙亚飞
杨灿
LIN Yongli;SUN Yafei;YANG Chan(Zhumadian Central Hospital in Henan Province,Zhumadian 463000)
出处
《陕西中医》
2019年第4期502-504,共3页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省科技攻关计划项目(122102310136)
关键词
慢性荨麻疹
自体血清皮肤实验(+)
中西医结合
自血穴位注射
依匹斯汀
脾氨肽
Chronic urticaria
Autologous serum skin test (+)
Integrated traditional Chinese and western medicine therapy
@Self-blood point injection
Ebastine
Spleen Aminopeptide
