摘要
目的对急诊科重症监护室(ICU)患者分离出的碳青霉烯耐药鲍曼不动杆菌(CRAB)进行流行病学调查。方法收集2015年12月至2016年5月北京大学第一医院急诊科ICU 23名患者的呼吸道分泌物标本,对分离到的CRAB进行纸片法抗菌药物敏感实验,并通过脉冲场凝胶电泳技术对菌株进行比对,确定菌株的同源性,同时结合临床资料进行分析。结果在23株CRAB中,14株来自同一克隆,提示该菌株为主要的流行株,其余均为散发菌株。在感染CRAB的23例患者中,有9例死亡。结论 CRAB感染多见于危重症患者,在急诊ICU呈现暴发流行,治疗困难,死亡风险高。
Objective To investigate the molecular epidemiology of car- bapenem - resistant Acinetobacter baumannii ( CRAB) infection in pa- tients in emergency intensive care unit( ICU). Methods A total of 23 CRAB strains were isolated from respiratory secretions of 23 patients in e- mergency ICU of Peking University First Hospital from December 2015 to May 2016. Antimicrobial susceptibility testing was performed by E - test method. Homology of the strains was analyzed by the methods of pulsed field gel electrophoresis with clinical data . Results Of the 23 patho- gens isolated from patients in emergency ICU,14 strains came from the same clone,suggesting that the strain was the main epidemic strain and the rest were sporadic strains. Of the 23 patients infected with CRAB,9 died. Conclusion CRAB infection is more common in critically ill patients. It is an outbreak and epidemic in emergency ICU,which is difficult to treatment and has a high death risk.
作者
李秀清
高磊
崔兰卿
孙立颖
汪波
熊辉
LI Xiu-qing;GAO Lei;CUI Lan-qing;SUN Li-ying;WANG Bo;XIONG Hui(Emergency Intensive Care Unit,Peking University First Hospital,Beijing 100034,China;Antiinfection Word,Peking University First Hospital,Beijing 100034,China;Institute ofClinical Pharmacology,Peking University First Hospital,Beijing 100034,China;Clinical Laboratory,Peking University First Hospital,Beijing 100034,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2019年第15期1588-1591,共4页
The Chinese Journal of Clinical Pharmacology
关键词
碳青霉烯耐药鲍曼不动杆菌
流行病学
脉冲场凝胶电泳
carbapenem-resistant Acinetobacter baumannii
molecular epidemiology
pulsed field gel electrophoresis
