摘要
目的对急性重度有机磷农药中毒所致呼吸衰竭的临床急诊急救策略与方法进行分析。方法该次研究对象为该院收治的80例急性重度有机磷农药中毒致呼吸衰竭患者,选择时间段为2017年10月-2018年10月,随机将患者分为40例对照组、40例观察组,将常规洗胃、肌注阿托品等治疗应用于对照组临床,观察组在对照组基础上联合机械通气治疗,对两组患者的临床治疗效果进行比较。结果与对照组相(80.0%)比,观察组患者的临床治疗总有效率(97.5%)更佳,差异有统计学意义(χ^2=5.465,P<0.05);治疗前两组患者血胆碱酯酶、生命体征的比较差异无统计学意义(P>0.05),治疗后观察组血胆碱酯酶(386.42±254.41)U/L、(92.21±3.22)%优于对照组(485.74±134.21)U/L、(82.36±3.25)%,差异有统计学意义(t=6.241、6.123,P<0.05);对照组和观察组患者不良情况发生率分别为20.0%vs 5.0%,差异有统计学意义(P<0.05);对照组意识恢复时间(52.14±13.26)h、自主呼吸恢复时间(51.36±12.42)h及CHE活力恢复60%的时间(135.25±23.15)h均长于观察组(36.42±12.45)h、(35.47±10.36)h、(118.26±25.54)h,差异有统计学意义(t=5.554、5.654、5.345,P<0.05)。结论为了提高急性重度有机磷农药中毒致呼吸衰竭患者的临床治疗效果,给予患者洗胃、阿托品肌注联合机械通气进行治疗十分有效,尤其体现在血胆碱酯酶、生命体征的改善等方面,该治疗方法具有的优势值得推广使用。
Objective To analyze the clinical emergency emergency strategies and methods for respiratory failure caused by acute severe organophosphorus pesticide poisoning.Methods The subjects of this study were 80 patients with respiratory failure caused by acute severe organophosphorus pesticide poisoning.The selection period was from October2017 to October 2018.The patients were randomly divided into 40 cases in the control group and 40 patients in the observation group,conventional gastric lavage,intramuscular atropine and other treatments were applied to the control group.The observation group was combined with mechanical ventilation on the basis of the control group,and the clinical treatment effects of the two groups were compared.Results Compared with the control group(80.0%),the total effective rate of clinical treatment(97.5%)was better in the observation group,the different was statistically significant(χ^2=5.465,P<0.05).The blood cholinesterase and vital signs of the two groups before treatment.There was no statistically significant difference(P>0.05).After treatment,the blood cholinesterase(386.42±254.41)U/L and(92.21±3.22)% were better than the control group(485.74±134.21)U/L,(82.36±3.25)%. The difference was statistically significant(t=6.241,6.123,P<0.05).The incidence of adverse events in the control group and the observation group were 20.0% vs 5.0%,the difference was statistically significant(P<0.05).The recovery time(52.14±13.26)h,spontaneous breathing recovery time(51.36±12.42)h and CHE activity recovery time of 60%(135.25±23.15)h in the control group longer than the obserution group(36.42±12.45)h,(35.47±10.36)h,(118.26±25.54)h,the difference was statistically significant(χ^2=5.554,5.654,5.345,P<0.05).Conclusion In order to improve the clinical treatment effect of patients with respiratory failure caused by acute severe organophosphorus pesticide poisoning,it is very effective to treat patients with gastric lavage and atropine intramuscular injection combined with mechanical ventilation,espec
作者
何继念
黄俊丽
HE Ji-nian;HUANG Jun-li(Department of Emergency, Chongqing Youyang County People's Hospital, Chongqing, 409800 China)
出处
《系统医学》
2019年第14期46-48,共3页
Systems Medicine
关键词
急性重度有机磷农药中毒
呼吸衰竭
急诊急救
Acute severe organophosphorus pesticide poisoning
Respiratory failure
Emergency first aid
