摘要
目的探讨急诊床边血液灌流治疗急性重度有机磷农药中毒的疗效。方法方便选择2016年1—12月80例急性重度有机磷农药中毒患者分组。对照组采用常规内科治疗方案,观察组则在对照组基础上采用急诊床边血液灌流治疗。比较两组急性重度有机磷农药中毒转归情况;呼吸机应用时间、清醒时间、24 h血清胆碱酯酶、阿托品用量;不良事件发生率。结果观察组急性重度有机磷农药中毒转归39例(97.50%)优于对照组30例(75.00%)(χ~2=8.538,P<0.05);观察组呼吸机应用时间、清醒时间短于对照组,24 h血清胆碱酯酶高于对照组,阿托品用量少于对照组,其中,观察组24 h血清胆碱酯酶、阿托品用量、清醒时间、呼吸机应用时间分别(25.01±8.41)U/L、(235.24±52.61)mg、(10.14±1.21)h、(76.23±11.62)h,对照组分别(15.23±4.13)U/L、(387.01±73.57)mg、(23.12±2.68)h、(157.10±22.51)h (t=5.224、6.013、5.724、6.824,P<0.05;观察组不良事件发生率2例(5.00%)少于对照组8例(20.00%)(χ~2=6.547,P<0.05)。结论急诊床边血液灌流治疗急性重度有机磷农药中毒的疗效确切,可有效缓解病情,减少阿托品用量,提高24小时血清胆碱酯酶,缩短清醒和呼吸机应用时间,减少不良事件的发生,值得推广。
Objective To investigate the efficacy of emergency bedside perfusion in the treatment of acute severe organophosphorus pesticide poisoning. Methods From January to December 2016, 80 patients with acute severe organophosphorus pesticide poisoning were convenient selected. The control group was treated with conventional medical treatment, and the observation group was treated with emergency bedside blood perfusion on the basis of the control group. The incidence of acute severe organophosphorus pesticide poisoning was compared between the two groups; ventilator application time, awake time, 24-hour serum cholinesterase, atropine dosage; incidence of adverse events. Results In the observation group, the acute organophosphorus pesticide poisoning was 39 ease （97.50%） better than the control group 30 ease （75.00%） （χ^2=8.538, P〈0.05）. The ventilator application time and waking time in the observation group were shorter than the control group, and the 24-hour serum biliary Alkaline esterase was higher than the control group, and the dosage of at- ropine was lower than that of the control group. Among them, the observation group had serum cholinesterase （U/L）, atropine dosage （rag）, awake time （h）, and ventilator application time （25.01±8.41）UL, （235.24±52.61）mg, （10.14±1.21）h, （76.23±11.62）h, respectively, the control group were （15.23±4.13）U/L, （387.01±73.57）mg, （23.12±2.68）h, （157.10±22.51）h, respectively （t=5.224, 6.013, 5.724, 6.824, P〈0.05）; the incidence of adverse events in the observation group was 2 ease （5.00%） less than that of the control group 8 case（20.00%）, （χ^2=6.547, P〈0.05）. Conclosion Emergency bedside hemopeffusion is effective in the treatment of acute severe organophosphorus pesticide poisoning. It can effectively alleviate the disease, reduce the dosage of atropine, increase the serum cholinesterase in 24 hours, shorten the application time of awake and ventilator, and reduce the occurrence of adverse events.
作者
张毅敏
ZHANG Yi-min(Department of Medical Sciences,Putian Emergency Center,Putian,Fujian Province,351100 China)
出处
《中外医疗》
2018年第26期60-62,共3页
China & Foreign Medical Treatment
关键词
急诊床边血液灌流
急性重度有机磷农药中毒
疗效
Emergency bedside blood perfusion
Acute severe organophosphorus pesticide poisoning
Efficacy
