摘要
目的研究缬沙坦与氨氯地平联合疗法在社区老年原发高血压合并糖尿病中的应用价值。方法随机选取2015年10月-2018年9月该社区医院接诊的老年原发高血压合并糖尿病患者380例,将之利用电脑随机双盲法分成实验组和对照两组(n=190)。实验组联合应用缬沙坦和氨氯地平,对照组单用氨氯地平。分析两组血压和血糖指标的改善情况,并对各组的生活质量评分等指标作出比较。结果实验组治疗后的收缩压水平为(115.24±5.16)mm Hg、舒张压水平为(70.18±4.23)mmHg,比对照组的(145.29±4.85)mmHg、(86.54±5.17)mmHg低(t1=58.491 7,t2=33.758 8,P<0.05)。实验组的治疗总有效率为94.74%,比对照组的76.32%高(χ^2=26.042,P<0.05)。实验组治疗后的空腹血糖水平为(6.68±1.65)mmol/L、餐后2 h血糖水平为(9.15±2.74)mmol/L,优于对照组的(9.53±2.57)mmol/L、(11.32±4.31)mmol/L,t1=12.862 9,t2=5.856 7,P<0.05)。实验组治疗后的生活质量评分为(88.56±4.12)分,比对照组的(80.73±4.63)分高(t=17.414 4,P<0.05)。结论联用缬沙坦和氨氯地平对社区老年原发高血压合并糖尿病患者进行治疗,可显著提升其血压和血糖指标的控制效果,促进临床症状与体征缓解,改善生活质量,建议临床推广。
Objective To study the value of combination of valsartan and amlodipine in the treatment of elderly patients with primary hypertension and diabetes mellitus. Methods A total of 380 elderly patients with primary hypertension and diabetes who were admitted to the community hospital from October 2015 to September 2018 were randomly selected and divided into experimental and control groups by computerized double-blind method (n=190). The experimental group was combined with valsartan and amlodipine, and the control group was treated with amlodipine alone. The improvement of blood pressure and blood glucose indicators in the two groups was analyzed, and the indicators of quality of life scores of each group were compared. Results The systolic blood pressure level of the experimental group was (115.24±5.16) mmHg and the diastolic blood pressure level was (70.18±4.23) mmHg, which was lower than that of the control group (145.29±4.85) mmHg,(86.54±5.17) mmHg(t=58.491 7, 33.758 8, P<0.05). The total effective rate of the experimental group was 94.74%, which was higher than 76.32% of the control group(χ^2=26.042, P<0.05). The fasting blood glucose level of the experimental group was (6.68±1.65)mmol/L, and the blood glucose level after 2 hours was (9.15±2.74) mmol/L, which was better than that of the control group (9.53±2.57) mmol/L,(11.32± 4.31) mmol/L(t=12.862 9, 5.856 7, P<0.05). The quality of life score of the experimental group after treatment was (88.56±4.12)points, which was higher than that of the control group (80.73±4.63)points(t=17.414 4, P<0.05). Conclusion The combination of valsartan and amlodipine in the treatment of elderly patients with primary hypertension and diabetes in the community can significantly improve the control of blood pressure and blood glucose, promote clinical symptoms and signs, improve quality of life, and recommend clinical promotion.
作者
耿文荣
GENG Wen-rong(Health and Medical Examination Department, Binzhou Maternal and Child Health Hospital, Binzhou, Shandong Province, 256600 China)
出处
《中外医疗》
2019年第20期10-12,共3页
China & Foreign Medical Treatment
关键词
老年原发高血压
缬沙坦
糖尿病
氨氯地平
Elderly essential hypertension
Valsartan
Diabetes
Amlodipine
