摘要
乳腺癌的发生、发展是多因素相互作用的复杂过程,肿瘤相关成纤维细胞(CAF)分泌多种因子可导致乳腺癌的发生,诱导肿瘤血管生成,促进肿瘤的转移,诱导肿瘤耐药;同时,亦可通过CAF的表达判断患者的临床预后.CAF有望成为肿瘤治疗的新靶点.
The occurrence and development of breast cancer is a complex process which referring to multi-factor interaction.During this process,cancer-associated fibroblasts (CAFs) secrect various growth factors and cytokines to promote the tumor progression,angiogenesis,metastasis,drug resistance.Meanwhile,it can also judge the prognosis of patients through the expression of CAFs.CAFs may offer a new therapeutic strategy against breast cancer.
作者
叶佳慧
张伟杰
Ye Jiahui;Zhang Weijie(Department of General Surgery,Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School,Nanjing University,Nanjing 210008,China)
出处
《国际肿瘤学杂志》
CAS
2019年第6期358-361,共4页
Journal of International Oncology
基金
国家自然科学基金(81672380).
关键词
癌相关成纤维细胞
乳腺肿瘤
肿瘤微环境
生物标记
预后
Cancer-associated fibroblasts
Breast neoplasms
Tumor microenvironment
Biomarkers
Prognosis
