摘要
中性粒细胞是循环中最为丰富的白细胞,在机体的免疫反应中发挥重要作用。中性粒细胞不仅参与免疫反应,也在肿瘤的发生发展,特别是侵袭和转移过程中发挥重要作用。中性粒细胞可分化为N1和N2亚型,在肿瘤的转移中表现出抑制转移(N1)和促进转移(N2)两种截然不同的的作用。但肿瘤相关中性粒细胞(tumor-associated neutrophils,TANs)在肿瘤转移机制中发挥的作用相对比较复杂,尚缺乏系统阐述。本文主要介绍TANs,分析其在肿瘤转移过程中促进肿瘤发生侵袭和转移的机制,对TANs作为抗肿瘤治疗策略的可能性进行综述。
Neutrophils are the most abundant leukocytes in the peripheral blood and play an important role in the immune response.However, there is growing evidence indicating that in addition to the immune response, neutrophils also have a crucial role in tumor development, especially in the process of invasion and metastasis. According to current research, depending on their phenotype, neutrophils appear to be either anti-metastasis(N1) or pro-metastasis(N2). However, the role of tumor-associated neutrophils(TANs) in the metastasis of tumors is relatively complex and lacks a systematic introduction. This review mainly introduces TANs and focuses on the mechanism of TANs in promoting tumor invasion and metastasis. Finally, the possibility of TANs as an anti-tumor treatment strategy is discussed.
作者
李佳庆
王清莹
程忠平
Jiaqing Li;Qingying Wang;Zhongping Cheng(Department of Gynaecology and Obstetrics,Affiliated Shanghai Tenth People's Hospital of Tongji University,Shanghai 200040,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2019年第10期524-527,共4页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金项目(编号:81874104)资助~~
关键词
肿瘤相关中性粒细胞
肿瘤
转移
机制
tumor-associated neutrophils(TANs)
tumor
metastasis
mechanism
